Laura C Bott
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Explore the profile of Laura C Bott including associated specialties, affiliations and a list of published articles.
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20
Citations
885
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Recent Articles
1.
Kitamura A, Fujimoto A, Kawashima R, Lyu Y, Sasaki K, Hamada Y, et al.
Commun Biol
. 2024 Jun;
7(1):743.
PMID: 38902525
Carboxy terminal fragments (CTFs) of TDP-43 contain an intrinsically disordered region (IDR) and form cytoplasmic condensates containing amyloid fibrils. Such condensates are toxic and associated with pathogenicity in amyotrophic lateral...
2.
Sala A, Grant R, Imran G, Morton C, Brielmann R, Gorgon S, et al.
Genes Dev
. 2024 May;
38(9-10):380-392.
PMID: 38816072
The ability to sense and respond to proteotoxic insults declines with age, leaving cells vulnerable to chronic and acute stressors. Reproductive cues modulate this decline in cellular proteostasis to influence...
3.
Sala A, Grant R, Imran G, Morton C, Brielmann R, Bott L, et al.
bioRxiv
. 2023 May;
PMID: 37162952
The ability to sense and respond to proteotoxic insults declines with age, leaving cells vulnerable to chronic and acute stressors. Reproductive cues modulate this decline in cellular proteostasis to influence...
4.
Bott L, Forouhan M, Lieto M, Sala A, Ellerington R, Johnson J, et al.
Brain Commun
. 2021 Dec;
3(4):fcab245.
PMID: 34909687
The vacuolar H-ATPase is a large multi-subunit proton pump, composed of an integral membrane V0 domain, involved in proton translocation, and a peripheral V1 domain, catalysing ATP hydrolysis. This complex...
5.
Sala A, Bott L, Brielmann R, Morimoto R
Genes Dev
. 2020 Mar;
34(9-10):678-687.
PMID: 32217667
The proteostasis network is regulated by transcellular communication to promote health and fitness in metazoans. In , signals from the germline initiate the decline of proteostasis and repression of cell...
6.
Pourshafie N, Lee P, Chen K, Harmison G, Bott L, Fischbeck K, et al.
J Vis Exp
. 2018 Aug;
(138).
PMID: 30148479
RNA interference via the endogenous miRNA pathway regulates gene expression by controlling protein synthesis through post-transcriptional gene silencing. In recent years, miRNA-mediated gene regulation has shown potential for treatment of...
7.
Belikov S, Bott L, Fischbeck K, Wrange O
Biochem Biophys Rep
. 2017 Nov;
3:134-139.
PMID: 29124176
Expansion of a polyglutamine-encoding trinucleotide CAG repeat in the androgen receptor (AR) to more than 37 repeats is responsible for the X-linked neuromuscular disease spinal and bulbar muscular atrophy (SBMA)....
8.
Sala A, Bott L, Morimoto R
J Cell Biol
. 2017 Apr;
216(5):1231-1241.
PMID: 28400444
The proteostasis network (PN) regulates protein synthesis, folding, transport, and degradation to maintain proteome integrity and limit the accumulation of protein aggregates, a hallmark of aging and degenerative diseases. In...
9.
Lanman T, Bakar D, Badders N, Burke A, Kokkinis A, Shrader J, et al.
J Neuromuscul Dis
. 2016 Nov;
3(1):121-125.
PMID: 27854206
Spinal and bulbar muscular atrophy is caused by polyglutamine expansion in the androgen receptor. As an X-linked disease dependent on androgens, symptoms and findings are only fully manifest in males....
10.
Bott L, Salomons F, Maric D, Liu Y, Merry D, Fischbeck K, et al.
Sci Rep
. 2016 Jun;
6:27703.
PMID: 27312068
Polyglutamine expansion in the androgen receptor (AR) causes spinal and bulbar muscular atrophy (SBMA), an X-linked neuromuscular disease that is fully manifest only in males. It has been suggested that...