Laszlo A Groh
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Explore the profile of Laszlo A Groh including associated specialties, affiliations and a list of published articles.
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18
Citations
816
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Recent Articles
1.
Roring R, Scognamiglio F, de Jong L, Groh L, Matzaraki V, Koeken V, et al.
J Leukoc Biol
. 2024 Nov;
PMID: 39531639
Trained immunity induces antigen-agnostic enhancement of host defense and protection against secondary infections, but inappropriate activation can contribute to the pathophysiology of inflammatory diseases. Tight regulation of trained immunity is...
2.
Albers-Warle K, Helder L, Groh L, Polat F, Panhuizen I, Snoeck M, et al.
Anesth Analg
. 2024 Oct;
140(1):185-196.
PMID: 39453841
Background: Colorectal surgery is associated with moderate-to-severe postoperative complications in over 25% of patients, predominantly infections. Monocyte epigenetic alterations leading to immune tolerance could explain postoperative increased susceptibility to infections....
3.
Fok E, Moorlag S, Negishi Y, Groh L, Dos Santos J, Grawe C, et al.
Nat Genet
. 2023 Dec;
56(1):85-99.
PMID: 38092881
Inflammation is characterized by a biphasic cycle consisting initially of a proinflammatory phase that is subsequently resolved by anti-inflammatory processes. Interleukin-1β (IL-1β) is a master regulator of proinflammation and is...
4.
Groh L, Willems L, Fintelman P, Reijnen M, El Messaoudi S, Warle M
Cardiol Ther
. 2023 Dec;
13(1):233-242.
PMID: 38055176
Introduction: Cardiovascular diseases (CVD) are the leading cause of death globally. Inflammation is an important driver of CVD where tissue damage may lead to the formation of deadly thrombi. Therefore,...
5.
Jacobs L, Wintjens M, Nagy M, Willems L, Ten Cate H, Spronk H, et al.
Front Immunol
. 2023 Oct;
14:1182182.
PMID: 37868959
Introduction: Comprehensive studies investigating sustained hypercoagulability, endothelial function, and/or inflammation in relation to post-COVID-19 (PCC) symptoms with a prolonged follow-up are currently lacking. Therefore, the aim of this single-centre cohort...
6.
Ferreira A, Kostidis S, Groh L, Koeken V, Bruno M, Baydemir I, et al.
Cell Rep
. 2023 Jun;
42(6):112658.
PMID: 37330914
Itaconate is an immunomodulatory metabolite produced by immune cells under microbial stimulation and certain pro-inflammatory conditions and triggers antioxidant and anti-inflammatory responses. We show that dimethyl itaconate, a derivative of...
7.
Schrijver D, Roring R, Deckers J, de Dreu A, Toner Y, Prevot G, et al.
Nat Biomed Eng
. 2023 Jun;
7(9):1097-1112.
PMID: 37291433
Immunoparalysis is a compensatory and persistent anti-inflammatory response to trauma, sepsis or another serious insult, which increases the risk of opportunistic infections, morbidity and mortality. Here, we show that in...
8.
Willems L, Jacobs L, Groh L, Ten Cate H, Spronk H, Wilson-Storey B, et al.
J Clin Med
. 2023 Feb;
12(4).
PMID: 36835948
Introduction: Among its effect on virtually all other organs, COVID-19 affects the cardiovascular system, potentially jeopardizing the cardiovascular health of millions. Previous research has shown no indication of macrovascular dysfunction...
9.
Willems L, Thijssen D, Groh L, Kooijman N, Ten Cate H, Spronk H, et al.
Front Cardiovasc Med
. 2022 Oct;
9:979819.
PMID: 36277757
Objective: Dual pathway inhibition (DPI) by combining acetylsalicylic acid (ASA) with low-dose rivaroxaban has been shown to reduce cardiovascular events in patients with peripheral arterial disease (PAD) when compared to...
10.
de Goede K, Harber K, Gorki F, Verberk S, Groh L, Keuning E, et al.
Biochim Biophys Acta Mol Basis Dis
. 2022 May;
1868(9):166427.
PMID: 35526742
Macrophages undergo extensive metabolic rewiring upon activation which assist the cell in roles beyond energy production and synthesis of anabolic building blocks. So-called immunometabolites that accumulate upon immune activation can...