Lars Malmstrom
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Explore the profile of Lars Malmstrom including associated specialties, affiliations and a list of published articles.
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84
Citations
3301
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Recent Articles
1.
Strobaek J, Tang D, Gueto-Tettay C, Gomez Toledo A, Olofsson B, Hartman E, et al.
Int J Mol Sci
. 2025 Feb;
26(4).
PMID: 40003954
Antibodies are critical to the host's immune defense against bacterial pathogens. Understanding the mechanisms of antibody-antigen interactions is essential for developing new targeted immunotherapies. Building computational workflows that can identify...
2.
Gomez Toledo A, Chowdhury S, Hjortswang E, Sorrentino J, Lewis N, Blackberg A, et al.
Nat Commun
. 2025 Feb;
16(1):1942.
PMID: 39994218
This study showcases an integrative mass spectrometry-based strategy combining systems antigenomics and systems serology to characterize human antibodies in clinical samples. This strategy involves using antibodies circulating in plasma to...
3.
Tang D, Khakzad H, Hjortswang E, Malmstrom L, Ekstrom S, Happonen L, et al.
Nat Commun
. 2024 Nov;
15(1):10212.
PMID: 39587097
Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host....
4.
Tang D, Gueto-Tettay C, Hjortswang E, Strobaek J, Ekstrom S, Happonen L, et al.
Anal Chem
. 2024 May;
96(22):9060-9068.
PMID: 38701337
An important element of antibody-guided vaccine design is the use of neutralizing or opsonic monoclonal antibodies to define protective epitopes in their native three-dimensional conformation. Here, we demonstrate a multimodal...
5.
Izadi A, Karami Y, Bratanis E, Wrighton S, Khakzad H, Nyblom M, et al.
Nat Commun
. 2024 Apr;
15(1):3600.
PMID: 38678029
Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the...
6.
Torres-Sangiao E, Happonen L, Heusel M, Palm F, Gueto-Tettay C, Malmstrom L, et al.
Mol Cell Proteomics
. 2024 Mar;
23(5):100753.
PMID: 38527648
Bacterial or viral antigens can contain subdominant protein regions that elicit weak antibody responses upon vaccination or infection although there is accumulating evidence that antibody responses against subdominant regions can...
7.
Hartman E, Scott A, Karlsson C, Mohanty T, Vaara S, Linder A, et al.
Nat Commun
. 2023 Sep;
14(1):5359.
PMID: 37660105
The incorporation of machine learning methods into proteomics workflows improves the identification of disease-relevant biomarkers and biological pathways. However, machine learning models, such as deep neural networks, typically suffer from...
8.
Mohanty T, Karlsson C, Chao Y, Malmstrom E, Bratanis E, Grentzmann A, et al.
Nat Commun
. 2023 Jun;
14(1):3603.
PMID: 37330510
Sepsis is the major cause of mortality across intensive care units globally, yet details of accompanying pathological molecular events remain unclear. This knowledge gap has resulted in ineffective biomarker development...
9.
Scott A, Karlsson C, Mohanty T, Hartman E, Vaara S, Linder A, et al.
Commun Biol
. 2023 Jun;
6(1):628.
PMID: 37301900
Data independent acquisition mass spectrometry (DIA-MS) has recently emerged as an important method for the identification of blood-based biomarkers. However, the large search space required to identify novel biomarkers from...
10.
Valencia-Gallardo C, Aguilar-Salvador D, Khakzad H, Cocom-Chan B, Bou-Nader C, Velours C, et al.
Cell Rep
. 2023 Apr;
42(4):112405.
PMID: 37071535
Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments. Here, we show...