Lars C Petersen
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Explore the profile of Lars C Petersen including associated specialties, affiliations and a list of published articles.
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32
Citations
766
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Recent Articles
1.
Jeppesen T, Kristensen L, Nielsen C, Petersen L, Kristensen J, Behrens C, et al.
Bioconjug Chem
. 2019 Jan;
30(3):775-784.
PMID: 30676028
A nonvolatile fluorine-18 aldehyde prosthetic group was developed from [F]SFB, and used for site-specific labeling of active site inhibited factor VII (FVIIai). FVIIai has a high affinity for tissue factor...
2.
Jeppesen T, Kristensen L, Nielsen C, Petersen L, Kristensen J, Behrens C, et al.
Bioconjug Chem
. 2017 Dec;
29(1):117-125.
PMID: 29206443
A method for site-specific radiolabeling of the serine protease active site inhibited factor seven (FVIIai) with Cu has been applied using a biorthogonal click reaction. FVIIai binds to tissue factor...
3.
Kamikubo Y, Mendolicchio G, Zampolli A, Marchese P, Rothmeier A, Orje J, et al.
Blood
. 2017 Jul;
130(14):1661-1670.
PMID: 28729433
Safe and effective antithrombotic therapy requires understanding of mechanisms that contribute to pathological thrombosis but have a lesser impact on hemostasis. We found that the extrinsic tissue factor (TF) coagulation...
4.
Nielsen C, Jeppesen T, Kristensen L, Jensen M, El Ali H, Madsen J, et al.
J Nucl Med
. 2016 Mar;
57(7):1112-9.
PMID: 27013699
Unlabelled: Tissue factor (TF) is the main initiator of the extrinsic coagulation cascade. However, TF also plays an important role in cancer. TF expression has been reported in 53%-89% of...
5.
Nielsen C, Erlandsson M, Jeppesen T, Jensen M, Kristensen L, Madsen J, et al.
J Nucl Med
. 2015 Sep;
57(1):89-95.
PMID: 26383146
Unlabelled: Tissue factor (TF) is upregulated in many solid tumors, and its expression is linked to tumor angiogenesis, invasion, metastasis, and prognosis. A noninvasive assessment of tumor TF expression status...
6.
Erlandsson M, Nielsen C, Jeppesen T, Kristensen J, Petersen L, Madsen J, et al.
J Labelled Comp Radiopharm
. 2015 Mar;
58(5):196-201.
PMID: 25820758
Activated factor VII blocked in the active site with Phe-Phe-Arg-chloromethyl ketone (active site inhibited factor VII (ASIS)) is a 50-kDa protein that binds with high affinity to its receptor, tissue...
7.
Zhu S, Kisiel W, Lu Y, Petersen L, Ndungu J, Moore T, et al.
J Drug Deliv
. 2015 Jan;
2014:865732.
PMID: 25574399
Breast cancer aberrantly expresses tissue factor (TF) in cancer tissues and cancer vascular endothelial cells (VECs). TF plays a central role in cancer angiogenesis, growth, and metastasis and, as such,...
8.
Zhu S, Kisiel W, Lu Y, Petersen L, Ndungu J, Moore T, et al.
J Drug Target
. 2014 Dec;
23(3):257-65.
PMID: 25510254
We have developed a specific technique for imaging cancer in vivo using Cy5.5-labeled factor VIIa (fVIIa), clotting-deficient FFRck-fVIIa, paclitaxel-FFRck-fVIIa, and anti-tissue factor (TF) antibody. FVIIa is the natural ligand for...
9.
Augustsson C, Hilden I, Petersen L
Thromb Res
. 2014 May;
134(1):132-7.
PMID: 24787991
Introduction: Tissue factor pathway inhibitor (TFPI) is present in plasma as full-length free TFPI (TFPIα) and as C-terminally degraded forms mainly associated with low-density lipoprotein particles (LDL-TFPI). Addition of TFPIα...
10.
de Oliveira A, Lima L, Mariano-Oliveira A, Machado D, Nasciutti L, Andersen J, et al.
Thromb Res
. 2012 Jun;
130(3):e163-70.
PMID: 22683021
Melanoma is a highly metastatic cancer and there is strong evidence that the clotting initiator protein, tissue factor (TF), contributes to its aggressive pattern. TF inhibitors may attenuate primary tumor...