Laramie E Duncan
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Explore the profile of Laramie E Duncan including associated specialties, affiliations and a list of published articles.
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36
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Recent Articles
1.
Duncan L, Li T, Salem M, Li W, Mortazavi L, Senturk H, et al.
Nat Neurosci
. 2025 Jan;
28(2):248-258.
PMID: 39833308
Psychiatric disorders are multifactorial and effective treatments are lacking. Probable contributing factors to the challenges in therapeutic development include the complexity of the human brain and the high polygenicity of...
2.
Nievergelt C, Maihofer A, Atkinson E, Chen C, Choi K, Coleman J, et al.
Nat Genet
. 2024 Apr;
56(5):792-808.
PMID: 38637617
Post-traumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed...
3.
Cusack S, Maihofer A, Bustamante D, Amstadter A, Duncan L
J Psychiatr Res
. 2024 Apr;
174:8-11.
PMID: 38598976
Females are twice as likely to experience PTSD as compared to males. Although sex differences in prevalence are well-established, little is known about why such sex differences occur. Biological factors...
4.
Guo M, Reynolds D, Ang C, Liu Y, Zhao Y, Donohue L, et al.
Nat Genet
. 2023 Oct;
55(11):1876-1891.
PMID: 37857935
Noncoding variants of presumed regulatory function contribute to the heritability of neuropsychiatric disease. A total of 2,221 noncoding variants connected to risk for ten neuropsychiatric disorders, including autism spectrum disorder,...
5.
Nievergelt C, Maihofer A, Atkinson E, Chen C, Choi K, Coleman J, et al.
medRxiv
. 2023 Sep;
PMID: 37693460
Posttraumatic stress disorder (PTSD) genetics are characterized by lower discoverability than most other psychiatric disorders. The contribution to biological understanding from previous genetic studies has thus been limited. We performed...
6.
Maihofer A, Choi K, Coleman J, Daskalakis N, Denckla C, Ketema E, et al.
Biol Psychiatry
. 2021 Dec;
91(7):626-636.
PMID: 34865855
Background: Posttraumatic stress disorder (PTSD) is heritable and a potential consequence of exposure to traumatic stress. Evidence suggests that a quantitative approach to PTSD phenotype measurement and incorporation of lifetime...
7.
Meijsen J, Shen H, Vemuri M, Rasgon N, Koenen K, Duncan L
Psychol Med
. 2021 Dec;
53(6):2241-2251.
PMID: 34865661
Background: Women experience major depression and post-traumatic stress disorder (PTSD) approximately twice as often as men. Estrogen is thought to contribute to sex differences in these disorders, and reduced estrogen...
8.
Martin J, Khramtsova E, Goleva S, Blokland G, Traglia M, Walters R, et al.
Biol Psychiatry
. 2021 Mar;
89(12):1127-1137.
PMID: 33648717
Background: The origin of sex differences in prevalence and presentation of neuropsychiatric and behavioral traits is largely unknown. Given established genetic contributions and correlations, we tested for a sex-differentiated genetic...
9.
Huckins L, Chatzinakos C, Breen M, Hartmann J, Klengel T, da Silva Almeida A, et al.
Cell Rep
. 2020 Jun;
31(9):107716.
PMID: 32492425
To reveal post-traumatic stress disorder (PTSD) genetic risk influences on tissue-specific gene expression, we use brain and non-brain transcriptomic imputation. We impute genetically regulated gene expression (GReX) in 29,539 PTSD...
10.
Sheerin C, Bountress K, Meyers J, Saenz de Viteri S, Shen H, Maihofer A, et al.
Psychol Addict Behav
. 2020 Mar;
34(5):613-619.
PMID: 32191043
Alcohol use disorder (AUD) and posttraumatic stress disorder (PTSD) frequently co-occur, highlighting the importance of understanding the etiology of these comorbid conditions. Although AUD and PTSD are moderately heritable with...