Lana M Osborn
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Explore the profile of Lana M Osborn including associated specialties, affiliations and a list of published articles.
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5
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511
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Recent Articles
1.
Huffels C, Osborn L, Cappaert N, Hol E
J Neurosci Res
. 2022 Mar;
100(6):1281-1295.
PMID: 35293016
Astrocytes are critical for healthy brain function. In Alzheimer's disease, astrocytes become reactive, which affects their signaling properties. Here, we measured spontaneous calcium transients ex vivo in hippocampal astrocytes in...
2.
Huffels C, Osborn L, Hulshof L, Kooijman L, Henning L, Steinhauser C, et al.
Glia
. 2022 Jan;
70(4):748-767.
PMID: 34981861
Alzheimer pathology is accompanied by astrogliosis. Reactive astrocytes surrounding amyloid plaques may directly affect neuronal communication, and one of the mechanisms by which astrocytes impact neuronal function is by affecting...
3.
Osborn L, Kamphuis W, Wadman W, Hol E
Prog Neurobiol
. 2016 Jan;
144:121-41.
PMID: 26797041
Alzheimer's disease is the main cause of dementia in the elderly and begins with a subtle decline in episodic memory followed by a more general decline in overall cognitive abilities....
4.
Orre M, Kamphuis W, Osborn L, Jansen A, Kooijman L, Bossers K, et al.
Neurobiol Aging
. 2014 Jul;
35(12):2746-2760.
PMID: 25002035
Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Yet, not much is known about the molecular alterations underlying this reactive phenotype. To get an insight...
5.
Orre M, Kamphuis W, Osborn L, Melief J, Kooijman L, Huitinga I, et al.
Neurobiol Aging
. 2013 Aug;
35(1):1-14.
PMID: 23954174
Astrocytes and microglia become reactive in many neurological disorders resulting in phenotypic and functional alterations. Both cell types might also display functional changes during normal aging. To identify gene signatures...