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Lamiaa E Abd El-Haleem

Explore the profile of Lamiaa E Abd El-Haleem including associated specialties, affiliations and a list of published articles. Areas
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1.
Alshammari M, Aly A, Brase S, Nieger M, Ibrahim M, Abd El-Haleem L
ACS Omega . 2022 Oct; 7(38):34463-34475. PMID: 36188271
New 1,4-naphthoquinone derived by triphenylphosphaneylidene (PhP) and -substituted-hydrazine-1-carbothioamides were obtained during a one-pot reaction of 2,3-dichloro-1,4-naphthoquinone with thiosemicarbazides, PhP and in the presence of triethyl amine (EtN) as a catalyst....
2.
Alshammari M, Aly A, Brase S, Nieger M, Abd El-Haleem L
ACS Omega . 2022 Apr; 7(15):12879-12890. PMID: 35474844
The strategies of the syntheses of various (thio)ureas, semicarbazides, thiosemicarbazides, thiazolidones, and oxadiazole derived from the [2.2]paracyclophane molecule are achieved starting with 4-(2.2]paracyclophanyl)isocyanate. The structures of the obtained products were...
3.
Ramadan M, Aly A, Abd El-Haleem L, Alshammari M, Brase S
Molecules . 2021 Aug; 26(16). PMID: 34443583
Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology...
4.
Aly A, Brase S, Hassan A, Mohamed N, Abd El-Haleem L, Nieger M, et al.
Molecules . 2020 Dec; 25(23). PMID: 33260954
Three new series of paracyclophanyl-dihydronaphtho[2,3-]thiazoles and paracyclophanyl-thiazolium bromides were designed, synthesized, and characterized by their spectroscopic data, along with X-ray analysis. One-dose assay results of anticancer activity indicated that -...
5.
Aly A, Brase S, Hassan A, Mohamed N, Abd El-Haleem L, Nieger M
Molecules . 2020 Jul; 25(15). PMID: 32707754
The manuscript describes the synthesis of new racemic and chiral linked paracyclophane assigned as -5-(1,4(1,4)-dibenzenacyclohexaphane-1-yl)carbamoyl)-5'-(1,4(1,4)-dibenzenacyclohexaphane-1-yl)carboxamide. The procedure depends upon the reaction of 5-(1,4(1,4)-dibenzenacyclohexaphane-1-yl)hydrazide with 5-(1,4(1,4)-dibenzenacyclohexaphane-1-yl)isocyanate. To prepare the homochiral linked...
6.
Aly A, Brase S, Hassan A, Mohamed N, Abd El-Haleem L, Nieger M, et al.
Molecules . 2020 Jul; 25(13). PMID: 32645912
A new series of methyl 2-(2-(4'-[2.2]paracyclophanyl)-hydrazinylidene)-3-substituted-4-oxothiazolidin-5-ylidene)acetates - were synthesized from the reaction of paracyclophanyl-acylthiosemicarbazides - with dimethyl acetylenedicarboxylate. Based upon nuclear magnetic resonance (NMR), infrared (IR), and mass spectra (HRMS),...
7.
Aly A, Hassan A, Mohamed N, Abd El-Haleem L, Brase S, Polamo M, et al.
Molecules . 2019 Oct; 24(20). PMID: 31640196
Herein, we report the synthesis of 5,12-dihydropyrazino[2,3-:5,6-']difuro[2,3-:4,5-']-diquinoline-6,14(,12)diones, 2-(4-hydroxy-2-oxo-1,2-dihydroquinolin-3-yl)-1,4-diphenyl- butane-1,4-diones and 4-(benzo-[]oxazol-2-yl)-3-hydroxy-1-[4,5]oxazolo[3,2-]pyridine-1-one. The new candidates were synthesized and identified by different spectroscopic techniques, and X-ray crystallography.