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Lambertus W P J van den Heuvel

Explore the profile of Lambertus W P J van den Heuvel including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 300
Followers 0
Related Specialties
Biochemistry
Biophysics
Cell Biology
Top 10 Co-Authors
Werner J H Koopman
Peter H G M Willems
Jan A M Smeitink
Sjenet E van Emst-de Vries
Sjoerd Verkaart
Henk-Jan Visch
Leo G J Nijtmans
Francois H van der Westhuizen
Julia Cheek
Michael P Murphy
Published In
Am J Physiol Cell Physiol
Biochim Biophys Acta
Biochim Biophys Acta Mol Basis Dis
Affiliations
Soon will be listed here.
Recent Articles
1.
Corrigendum to "Superoxide production is inversely related to complex I activity in inherited complex I deficiency" [Biochim Biophys Acta. 1772 (3) (2007) 373-381]
Verkaart S, Koopman W, van Emst-de Vries S, Nijtmans L, van den Heuvel L, Smeitink J, et al.
Biochim Biophys Acta Mol Basis Dis . 2020 Dec; 1867(3):166015. PMID: 33303240
No abstract available.
2.
Mitochondrial and cytosolic thiol redox state are not detectably altered in isolated human NADH:ubiquinone oxidoreductase deficiency
Verkaart S, Koopman W, Cheek J, van Emst-de Vries S, van den Heuvel L, Smeitink J, et al.
Biochim Biophys Acta . 2007 Jun; 1772(9):1041-51. PMID: 17600689
Isolated complex I deficiency is the most common enzymatic defect of the oxidative phosphorylation (OXPHOS) system, causing a wide range of clinical phenotypes. We reported before that the rates at...
3.
Superoxide production is inversely related to complex I activity in inherited complex I deficiency
Verkaart S, Koopman W, van Emst-de Vries S, Nijtmans L, van den Heuvel L, Smeitink J, et al.
Biochim Biophys Acta . 2007 Feb; 1772(3):373-81. PMID: 17289351
Deficiency of NADH:ubiquinone oxidoreductase or complex I (CI) is the most common cause of disorders of the oxidative phosphorylation system in humans. Using life cell imaging and blue-native electrophoresis we...
4.
Ca2+-mobilizing agonists increase mitochondrial ATP production to accelerate cytosolic Ca2+ removal: aberrations in human complex I deficiency
Visch H, Koopman W, Zeegers D, van Emst-de Vries S, van Kuppeveld F, van den Heuvel L, et al.
Am J Physiol Cell Physiol . 2006 Mar; 291(2):C308-16. PMID: 16554405
Previously, we reported that both the bradykinin (Bk)-induced increase in mitochondrial ATP concentration ([ATP]M) and the rate of cytosolic Ca2+ removal are significantly decreased in skin fibroblasts from a patient...
5.
Decreased agonist-stimulated mitochondrial ATP production caused by a pathological reduction in endoplasmic reticulum calcium content in human complex I deficiency
Visch H, Koopman W, Leusink A, van Emst-de Vries S, van den Heuvel L, Willems P, et al.
Biochim Biophys Acta . 2005 Oct; 1762(1):115-23. PMID: 16213125
Although a large number of mutations causing malfunction of complex I (NADH:ubiquinone oxidoreductase) of the OXPHOS system is now known, their cell biological consequences remain obscure. We previously showed that...
6.
Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency
Koopman W, Visch H, Verkaart S, van den Heuvel L, Smeitink J, Willems P
Am J Physiol Cell Physiol . 2005 May; 289(4):C881-90. PMID: 15901599
Complex I (NADH:ubiquinone oxidoreductase) is the largest multisubunit assembly of the oxidative phosphorylation system, and its malfunction is associated with a wide variety of clinical syndromes ranging from highly progressive,...
7.
Inhibition of complex I of the electron transport chain causes O2-. -mediated mitochondrial outgrowth
Koopman W, Verkaart S, Visch H, van der Westhuizen F, Murphy M, van den Heuvel L, et al.
Am J Physiol Cell Physiol . 2005 Jan; 288(6):C1440-50. PMID: 15647387
Recent evidence indicates that oxidative stress is central to the pathogenesis of a wide variety of degenerative diseases, aging, and cancer. Oxidative stress occurs when the delicate balance between production...