Lalitha Guruprasad
Overview
Explore the profile of Lalitha Guruprasad including associated specialties, affiliations and a list of published articles.
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Articles
64
Citations
490
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Recent Articles
1.
Pagag J, Andola P, Durgam L, Guruprasad L
J Biomol Struct Dyn
. 2024 Dec;
:1-15.
PMID: 39688508
According to World Health Organization reports of the year 2022, nearly 242,000 people died from hepatitis C that causes liver cirrhosis and hepatocellular carcinoma. Phosphatidylinositol-4-kinase type III alpha (PI4KIIIα), a...
2.
Naresh G, Guruprasad L
J Biomol Struct Dyn
. 2024 Dec;
:1-14.
PMID: 39681465
A kinase domain from receptor tyrosine kinases (RTKs) regulate intracellular communications to control cellular metabolic activities. Some of the malignant cells have upregulated and overexpressed RTKs which are responsible for...
3.
Malanchuk O, Bdzhola A, Palchevskyi S, Bdzhola V, Chai P, Pardo O, et al.
Int J Mol Sci
. 2024 Aug;
25(16).
PMID: 39201434
Ribosomal protein S6 kinases belong to a family of highly conserved enzymes in eukaryotes that regulate cell growth, proliferation, survival, and the stress response. It is well established that the...
4.
Gariganti N, Bandi A, Gatta K, Pagag J, Guruprasad L, Poola B, et al.
Heliyon
. 2024 May;
10(9):e30292.
PMID: 38711664
Cancer is a broad classification of diseases that can affect any organ or body tissue due to aberrant cellular proliferation for unknown reasons. Many present chemotherapeutic drugs are highly toxic...
5.
Guruprasad L, Naresh G, Boggarapu G
Curr Res Struct Biol
. 2023 Oct;
6:100107.
PMID: 37841365
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causative agent of the coronavirus disease-2019 (COVID-19) has resulted in several deaths and severe economic losses throughout the world. The spike protein in...
6.
Durgam L, Pagag J, Indra Neela Y, Guruprasad L
J Biomol Struct Dyn
. 2023 Sep;
42(19):9873-9891.
PMID: 37712848
Zika virus is responsible for causing Zika infections and was declared as a public health emergency of international concern in February 2016. The Zika virus NS3-helicase is a viable drug...
7.
Naresh G, Guruprasad L
J Biomol Struct Dyn
. 2023 Jan;
41(21):11394-11414.
PMID: 36591700
The dynamically active and inactive conformations of kinases play a crucial role in the activation of intracellular downstream signaling pathways. The all-atom molecular dynamics (MD) simulations at microsecond (µs) timescale...
8.
Andola P, Pagag J, Laxman D, Guruprasad L
Struct Chem
. 2022 Jul;
33(5):1467-1487.
PMID: 35811782
Supplementary Information: The online version contains supplementary material available at 10.1007/s11224-022-01995-z.
9.
Ommi N, Abdullah M, Guruprasad L, Prakash Babu P
Parasitol Int
. 2022 Apr;
89:102581.
PMID: 35395394
The present study investigates the potential effect of externally added unsaturated fatty acids on P. falciparum growth. Our results indicate that polyunsaturated fatty acids (PUFAs) inhibit the growth of Plasmodium...
10.
Durgam L, Guruprasad L
J Biomol Struct Dyn
. 2022 Mar;
41(9):3741-3751.
PMID: 35333147
The pandemic coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in more than 5 million deaths globally. Currently there are no effective drugs available...