Lakshay Malhotra
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Explore the profile of Lakshay Malhotra including associated specialties, affiliations and a list of published articles.
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10
Citations
20
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Recent Articles
1.
Singh A, Malhotra L, Mishra A, Kundral S, Tiwari P, Kumar S, et al.
Arch Biochem Biophys
. 2025 Mar;
768:110381.
PMID: 40064360
The homotetrameric form of p53 is critical for performing essential functions like maintaining genomic stability and preventing uncontrolled cell proliferation. In part, these crucial functions are mediated by the p53 ...
2.
Malhotra L, Singh A, Kaur P, Ethayathulla A
J Biomol Struct Dyn
. 2024 Dec;
:1-14.
PMID: 39639563
The p53 tumor suppressor is one of the most mutated genes responsible for tumorigenesis in most human cancers. Out of 29,891 genomic mutations reported in the TP53 Database (https://tp53.isb-cgc.org/), 1,297...
3.
Chauhan R, Malhotra L, Gupta A, Dagar G, Mendiratta M, Masoodi T, et al.
Sci Rep
. 2024 Jul;
14(1):15287.
PMID: 38961106
Cervical cancer is still the leading cause of cancer mortality worldwide even after introduction of vaccine against Human papillomavirus (HPV), due to low vaccine coverage, especially in the developing world....
4.
Sharma P, Malhotra L, Dhamija R
J Biomol Struct Dyn
. 2024 Jan;
43(7):3715-3727.
PMID: 38178552
The seed storage proteins of cereal and legumes are the primary source of amino acids which are required for sustaining the nitrogen and carbon demands during germination and growth. Humans...
5.
Malhotra L, Kaur P, Ethayathulla A
J Biomol Struct Dyn
. 2023 Aug;
42(18):9602-9613.
PMID: 37643005
The p53 Y220C is one of the most frequently observed structural mutants in various human cancers. The substitution of residue Tyr to Cys makes the p53 DNA binding domain susceptible...
6.
Chauhan R, Gupta A, Malhotra L, Bhat A, Pandita R, Masoodi T, et al.
J Transl Med
. 2023 Apr;
21(1):286.
PMID: 37118828
Background: Osteosarcoma is a type of bone cancer that predominantly affects young individuals, including children and adolescents. The disease progresses through heterogeneous genetic alterations, and patients often develop pulmonary metastases...
7.
Sharma S, Malhotra L, Mukherjee P, Kaur N, Krishanlata T, Srikanth C, et al.
Int J Biol Macromol
. 2023 Feb;
235:123670.
PMID: 36796556
The unregulated use of organochlorine pesticides (OCPs) has been linked to spread of breast cancer (BC), but the underlying biomolecular interactions are unknown. Using a case-control study, we compared OCP...
8.
Malhotra L, Sharma S, Hariprasad G, Dhingra R, Mishra V, Sharma R, et al.
Biochim Biophys Acta Mol Cell Res
. 2022 Aug;
1869(12):119343.
PMID: 36007676
The mutant p53Y220C (mutp53Y220C) is frequently observed in numerous tumors, including pancreatic cancer. The mutation creates a crevice in the DNA binding core domain and makes p53 a thermally unstable...
9.
Malhotra L, Singh A, Kaur P, Ethayathulla A
Brief Funct Genomics
. 2022 Jul;
22(2):97-108.
PMID: 35809339
The p53 is the master regulator of the cell known for regulating a large array of cellular processes. Inactivation of p53 by missense mutations is one of the leading causes...
10.
Singh M, Malhotra L, Haque M, Kumar M, Tikhomirov A, Litvinova V, et al.
Biochimie
. 2021 Jan;
182:152-165.
PMID: 33417980
The quest for effective anticancer therapeutics continues to be extensively pursued. Over the past century, several drugs have been developed, however, a majority of these drugs have a poor therapeutic...