Lai Ping Wong
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Explore the profile of Lai Ping Wong including associated specialties, affiliations and a list of published articles.
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19
Citations
385
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Recent Articles
1.
Fukushima T, Kristiansen T, Wong L, Keyes S, Tanaka Y, Mazzola M, et al.
bioRxiv
. 2025 Mar;
PMID: 40027782
Transitions between subsets of differentiating hematopoietic cells are widely regarded as unidirectional . Here, we introduce clonal phylogenetic tracer (CP-tracer) that sequentially introduces genetic barcodes, enabling high-resolution analysis of ~100,000...
2.
Shih Y, Alipio J, Alipio J, Klaft Z, Green N, Wong L, et al.
Res Sq
. 2025 Jan;
PMID: 39877097
The hippocampus forms memories of our experiences by registering processed sensory information in coactive populations of excitatory principal cells or ensembles. Fast-spiking parvalbumin-expressing inhibitory neurons (PV INs) in the dentate...
3.
Ferrer C, Cho H, Boon R, Bernasocchi T, Wong L, Cetinbas M, et al.
Nat Cell Biol
. 2024 Jun;
26(6):975-990.
PMID: 38862786
Identifying the adaptive mechanisms of metastatic cancer cells remains an elusive question in the treatment of metastatic disease, particularly in pancreatic cancer (pancreatic adenocarcinoma, PDA). A loss-of-function shRNA targeted screen...
4.
Zhu Y, Speir M, Tan Z, Lee J, Nowell C, Chen A, et al.
Sci Adv
. 2023 Dec;
9(51):eadj1397.
PMID: 38117877
Neutrophil extracellular traps (NETs) not only counteract bacterial and fungal pathogens but can also promote thrombosis, autoimmunity, and sterile inflammation. The presence of citrullinated histones, generated by the peptidylarginine deiminase...
5.
Hoetker M, Yagi M, Di Stefano B, Langerman J, Cristea S, Wong L, et al.
Nat Cell Biol
. 2023 Jul;
25(8):1121-1134.
PMID: 37460697
The epigenetic mechanisms that maintain differentiated cell states remain incompletely understood. Here we employed histone mutants to uncover a crucial role for H3K36 methylation in the maintenance of cell identities...
6.
Rhee C, Scadden E, Wong L, Schiroli G, Mazzola M, Chea P, et al.
Blood
. 2023 Jun;
142(7):658-674.
PMID: 37267513
Myeloid cell heterogeneity is known, but whether it is cell-intrinsic or environmentally-directed remains unclear. Here, an inducible/reversible system pausing myeloid differentiation allowed the definition of clone-specific functions that clustered monocytes...
7.
Nakazawa H, Wong L, Shelton L, Sadreyev R, Kaneki M
Metabolites
. 2022 Sep;
12(9).
PMID: 36144205
Burn injury remains a significant public health issue worldwide. Metabolic derangements are a major complication of burn injury and negatively affect the clinical outcomes of severely burned patients. These metabolic...
8.
Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F, Bonilla G, et al.
Cell
. 2022 Aug;
185(17):3232-3247.e18.
PMID: 35952671
How mis-regulated chromatin directly impacts human immune disorders is poorly understood. Speckled Protein 140 (SP140) is an immune-restricted PHD and bromodomain-containing epigenetic "reader," and SP140 loss-of-function mutations associate with Crohn's...
9.
Kim M, Kim M, Salloum S, Qian T, Wong L, Xu M, et al.
Hepatol Commun
. 2022 Jun;
6(9):2581-2593.
PMID: 35712812
Lipophilic but not hydrophilic statins have been shown to be associated with reduced risk for hepatocellular carcinoma (HCC) in patients with chronic viral hepatitis. We investigated differential actions of lipophilic...
10.
Poller W, Downey J, Mooslechner A, Khan N, Li L, Chan C, et al.
Nature
. 2022 May;
607(7919):578-584.
PMID: 35636458
The nervous and immune systems are intricately linked. Although psychological stress is known to modulate immune function, mechanistic pathways linking stress networks in the brain to peripheral leukocytes remain poorly...