Lacramioara Ivanciu
Overview
Explore the profile of Lacramioara Ivanciu including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
877
Followers
0
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Recent Articles
1.
Poncz M, Zaitsev S, Ahn H, Kowalska M, Bdeir K, Dergilev K, et al.
Blood Adv
. 2024 May;
8(14):3798-3809.
PMID: 38805575
Fibrinolytics delivered into the general circulation lack selectivity for nascent thrombi, reducing efficacy and increasing the risk of bleeding. Urokinase-type plasminogen activator (uPA) transgenically expressed within murine platelets provided targeted...
2.
3.
Ivanciu L, Arruda V, Camire R
Blood
. 2023 Feb;
141(16):2022-2032.
PMID: 36724452
Factor IXa (FIXa) plays a pivotal role in coagulation by contributing to FX activation via the intrinsic pathway. Although antithrombin (AT) and other plasma inhibitors are thought to regulate FIXa...
4.
Yu X, Panckeri K, Ivanciu L, Camire R, Coxon C, Cuker A, et al.
Res Pract Thromb Haemost
. 2020 Jan;
4(1):54-63.
PMID: 31989085
Background: Microfluidic clotting assays permit drug action studies for hemophilia therapeutics under flow. However, limited availability of patient samples and Inter-donor variability limit the application of such assays, especially with...
5.
Brake M, Ivanciu L, Maroney S, Martinez N, Mast A, Westrick R
Curr Protoc Mouse Biol
. 2019 Mar;
9(2):e61.
PMID: 30875463
The mammalian blood coagulation system was designed to restrict blood loss due to injury as well as keep the blood fluid within the blood vessels of the organism. Blood coagulation...
6.
Polderdijk S, Adams T, Ivanciu L, Camire R, Baglin T, Huntington J
Blood
. 2016 Oct;
129(1):105-113.
PMID: 27789479
Hemophilia is a bleeding disorder caused by deficiency in factors VIII or IX, the two components of the intrinsic Xase complex. Treatment with replacement factor can lead to the development...
7.
Thalji N, Ivanciu L, Davidson R, Gimotty P, Krishnaswamy S, Camire R
Nat Med
. 2016 Jul;
22(8):924-32.
PMID: 27455511
Direct inhibitors of coagulation factor Xa (FXa) or thrombin are promising oral anticoagulants that are becoming widely adopted. The ability to reverse their anticoagulant effects is important when serious bleeding...
8.
Hui D, Edmonson S, Podsakoff G, Pien G, Ivanciu L, Camire R, et al.
Mol Ther Methods Clin Dev
. 2015 Oct;
2:15029.
PMID: 26445723
Adeno-associated virus (AAV) has become one of the most promising vectors in gene transfer in the last 10 years with successful translation to clinical trials in humans and even market...
9.
Ivanciu L, Camire R
Blood
. 2015 Apr;
126(1):94-102.
PMID: 25896653
There is a clinical need to develop safe therapeutic strategies to mitigate bleeding. Previously, we found that a novel zymogen-like factor Xa variant (FXa-I16L) was effective in correcting the coagulation...
10.
Sehgal A, Barros S, Ivanciu L, Cooley B, Qin J, Racie T, et al.
Nat Med
. 2015 Apr;
21(5):492-7.
PMID: 25849132
Hemophilia A and B are inherited bleeding disorders characterized by deficiencies in procoagulant factor VIII (FVIII) or factor IX (FIX), respectively. There remains a substantial unmet medical need in hemophilia,...