L Sefc
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Explore the profile of L Sefc including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
21
Citations
94
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0
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Recent Articles
11.
Shchemelinin I, Sefc L, Necas E
Folia Biol (Praha)
. 2006 Nov;
52(4):137-48.
PMID: 17116285
Since protein kinases have been found to be implicated in many diseases, first of all malignancies, they are considered as promising therapeutic targets. Many protein kinase inhibitors have been designed...
12.
Shchemelinin I, Sefc L, Necas E
Folia Biol (Praha)
. 2006 Nov;
52(3):81-100.
PMID: 17089919
Protein phosphorylation is known to play an important role in various cellular processes such as cell division, metabolism, survival and apoptosis. It is driven by specific enzymes, tyrosine and serine-threonine...
13.
Krijt J, Vokurka M, Sefc L, Duricova D, Necas E
Folia Biol (Praha)
. 2006 Sep;
52(1-2):1-5.
PMID: 17007103
Haem carrier protein 1 (Hcpl) is a component of the haem-iron uptake pathway in the small intestine. Using quantitative real-time PCR, we examined the expression of Hcp1 and other intestinal...
14.
Psenak O, Sefc L, Sykora V, Chang K, Necas E
Acta Haematol
. 2003 Mar;
109(2):68-75.
PMID: 12624490
The goal of the study was to investigate changes in expression of selected growth factors tentatively involved in regeneration of haematopoietic tissues (bone marrow and spleen) following cyclophosphamide (CY) damage...
15.
Sefc L, Pradny M, Vacik J, Michalek J, Povysil C, Vitkova I, et al.
Biomaterials
. 2002 Jul;
23(17):3711-5.
PMID: 12109696
Hydrogel implants for urinary incontinence treatment based on HEMA supplemented with 10% methacrylic acid have been developed. The swelling properties of implants were tested in vitro and in vivo after...
16.
Rihova Z, Sefc L, Necvas E
Cas Lek Cesk
. 2001 May;
140(6):168-72.
PMID: 11347206
Apoptosis is a physiological form of cell death, whose dysregulation may lead to cancer or to autoimmune and degenerative diseases. In this review article, distinctive biochemical, molecular and morphological features...
17.
Necas E, Sefc L, SULC K, Barthel E, Seidel H
Stem Cells
. 1998 Apr;
16(2):107-11.
PMID: 9554034
Murine hematopoiesis has been analyzed by many authors, and available data allow for quantitative evaluation of this dynamic process. In this study, the capacity of several populations of the bone...
18.
Necas E, Sefc L, BRECHER G, Bookstein N
Exp Hematol
. 1995 Nov;
23(12):1242-6.
PMID: 7589277
Using quantitative data available from the literature on murine hematopoiesis, the functional reserve of multipotential stem cells was calculated by comparing daily blood cell production with the potential of clonogenic...
19.
Necas E, Sefc L, Znojil V
Stem Cells
. 1993 Jul;
11(4):319-25.
PMID: 8401255
Hematopoietic cells, detected as spleen colony forming units (CFU-S), vary in their proliferation rate, and this can be investigated in vivo by determining the fraction of CFU-S synthesizing DNA. A...
20.
Necas E, Znojil V, Sefc L
Cell Tissue Kinet
. 1990 Nov;
23(6):637-49.
PMID: 2276177
The haemopoietic stem cells forming spleen colonies (CFU-S) had on average 30 to 40% of cells engaged in the DNA synthesis in normal mice continuously over 4 years. A majority...