L Ramdas
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Explore the profile of L Ramdas including associated specialties, affiliations and a list of published articles.
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21
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112
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Recent Articles
1.
Ramdas L, Coombes K, Baggerly K, Abruzzo L, Highsmith W, Krogmann T, et al.
Genome Biol
. 2001 Dec;
2(11):RESEARCH0047.
PMID: 11737946
Background: A key assumption in the analysis of microarray data is that the quantified signal intensities are linearly related to the expression levels of the corresponding genes. To test this...
2.
Ramdas L, Wang J, Hu L, Cogdell D, Taylor E, Zhang W
Biotechniques
. 2001 Sep;
31(3):546, 548, 550, passim.
PMID: 11570499
Laboratories use different laser-based scanners to scan microarray images. To assess whether results from different scanners are comparable, and thus whether data from different laboratories can be compared, we scanned...
3.
Taylor E, Cogdell D, Coombes K, Hu L, Ramdas L, Tabor A, et al.
Biotechniques
. 2001 Jul;
31(1):62-5.
PMID: 11464521
To generate cDNA arrays in our core laboratory, we amplified about 2300 PCR products from a human, sequence-verified cDNA clone library. As a quality-control step, we sequenced the PCR products...
4.
Wang W, Ramdas L, Sun G, Ke S, Obeyesekere N, Budde R, et al.
Biochemistry
. 2000 May;
39(17):5221-8.
PMID: 10819990
The protein tyrosine kinase, pp60(c-)(src), is involved in cellular signaling and is activated during mitosis and in various tumors. We have been employing cyclic decapeptides to identify the determinants for...
5.
Ramdas L, Bunnin B, Plunkett M, Sun G, ELLMAN J, Gallick G, et al.
Arch Biochem Biophys
. 1999 Aug;
368(2):394-400.
PMID: 10441393
We screened 1680 spatially separated compounds of a diverse combinatorial library of 1,4-benzodiazepines for their ability to inhibit the kinase activity of protein tyrosine kinases Src, Yes, Abl, Lck, Csk,...
6.
Ramdas L, Obeyesekere N, Sun G, McMurray J, Budde R
J Pept Res
. 1999 Jul;
53(5):569-77.
PMID: 10424353
The conversion of a peptide substrate to a potent inhibitor by chemical modification is a promising approach in the development of inhibitors for protein tyrosine kinases. N-acylation of the synthetic...
7.
Ramdas L, Budde R
Cancer Biochem Biophys
. 1999 Jan;
16(4):375-85.
PMID: 9925284
Inhibition of the tyrosine kinase activity of Src by forty-three different compounds from five chemical families (cinnamic acid, salicylic acid, phenol, coumarin and flavonoid derivatives) representing plant and microbial secondary...
8.
McMurray J, Budde R, Ke S, Obeyesekere N, Wang W, Ramdas L, et al.
Arch Biochem Biophys
. 1998 Jul;
355(1):124-30.
PMID: 9647675
A series of 48 cyclic peptides based on the amino acid sequence surrounding the autophosphorylation site of pp60(c-src) was synthesized and each was tested as both a substrate and an...
9.
10.
Ramdas L, Obeyesekere N, McMurray J, Budde R
Arch Biochem Biophys
. 1996 Feb;
326(1):73-8.
PMID: 8579374
We used a novel approach to determine the minimal size and semioptimal sequence of a peptide to serve as an inhibitor and/or substrate for the protein tyrosine kinase pp60c-src. The...