L P Shearman
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Explore the profile of L P Shearman including associated specialties, affiliations and a list of published articles.
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23
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2466
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Recent Articles
1.
Shearman L, Rosko K, Fleischer R, Wang J, Xu S, Tong X, et al.
Behav Pharmacol
. 2003 Dec;
14(8):573-82.
PMID: 14665974
Psychopathological disorders, and depression in particular, are strongly linked to eating attitude in obese patients. The identification of cannabinoid CB1 receptors (CB1Rs) in areas of the central nervous system (CNS)...
2.
Wu K, Shearman L, Camacho R, Tota M, Fong T, van der Ploeg L
J Neuroendocrinol
. 2002 Aug;
14(8):607-10.
PMID: 12153462
We measured plasma concentrations of agouti-related protein (AGRP) in humans and rats and determined whether these were affected by ingestion of a meal after fasting. In 17 healthy human subjects,...
3.
Shearman L, Weaver D
J Biol Rhythms
. 2002 Jan;
16(6):531-40.
PMID: 11760011
Maternal treatment with cocaine or a D1-dopamine receptor agonist induces c-fos gene expression in the fetal suprachiasmatic nuclei (SCN). Other treatments that induce c-fos expression in the fetal SCN include...
4.
Shearman L, Jin X, Lee C, Reppert S, Weaver D
Mol Cell Biol
. 2000 Aug;
20(17):6269-75.
PMID: 10938103
Neurons in the mammalian suprachiasmatic nucleus (SCN) contain a cell-autonomous circadian clock that is based on a transcriptional-translational feedback loop. The basic helix-loop-helix-PAS proteins CLOCK and BMAL1 are positive regulators...
5.
Shearman L, Sriram S, Weaver D, Maywood E, Chaves I, Zheng B, et al.
Science
. 2000 May;
288(5468):1013-9.
PMID: 10807566
We show that, in the mouse, the core mechanism for the master circadian clock consists of interacting positive and negative transcription and translation feedback loops. Analysis of Clock/Clock mutant mice,...
6.
Ripperger J, Shearman L, Reppert S, Schibler U
Genes Dev
. 2000 Mar;
14(6):679-89.
PMID: 10733528
DBP, the founding member of the PAR leucine zipper transcription factor family, is expressed according to a robust daily rhythm in the suprachiasmatic nucleus and several peripheral tissues. Previous studies...
7.
Shearman L, Meyer J
Eur J Pharmacol
. 1999 Dec;
386(1):1-6.
PMID: 10611457
We investigated the influence of 3 days of continuous cocaine exposure on norepinephrine transporter binding in the rat placenta. On gestational day 17, pregnant rats were implanted subcutaneously with two...
8.
Kume K, Zylka M, Sriram S, Shearman L, Weaver D, Jin X, et al.
Cell
. 1999 Jul;
98(2):193-205.
PMID: 10428031
We determined that two mouse cryptochrome genes, mCry1 and mCry2, act in the negative limb of the clock feedback loop. In cell lines, mPER proteins (alone or in combination) have...
9.
Shearman L, Weaver D
Neuroreport
. 1999 Apr;
10(3):613-8.
PMID: 10208599
The Clock mutation leads to abnormal circadian behavior and defective transcriptional activity of CLOCK, a basic helix-loop-helix (bHLH)/PAS protein. In situ hybridization was used to assess whether the Clock mutation...
10.
Shearman L, Zylka M, Reppert S, Weaver D
Neuroscience
. 1999 Mar;
89(2):387-97.
PMID: 10077321
The suprachiasmatic nuclei contain a circadian clock that drives rhythmicity in physiology and behavior. In mice, mutation of the Clock gene produces abnormal circadian behavior [Vitaterna M. H. et al....