L Lorand
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Explore the profile of L Lorand including associated specialties, affiliations and a list of published articles.
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184
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2367
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Recent Articles
11.
Murthy S, Wilson J, Lukas T, Veklich Y, Weisel J, Lorand L
Proc Natl Acad Sci U S A
. 2000 Jan;
97(1):44-8.
PMID: 10618368
Studies on transglutaminases usually focus on the polymerization of protein substrates by intermolecular N(epsilon)(gamma-glutamyl)lysine bridges, without considering the possibility that the monomeric protein units, themselves, could also become crosslinked internally....
12.
Ryan E, Mockros L, Stern A, Lorand L
Biophys J
. 1999 Nov;
77(5):2827-36.
PMID: 10545380
We investigated the origins of greater clot rigidity associated with FXIIIa-dependent cross-linking. Fibrin clots were examined in which cross-linking was controlled through the use of two inhibitors: a highly specific...
13.
Ryan E, Mockros L, Weisel J, Lorand L
Biophys J
. 1999 Nov;
77(5):2813-26.
PMID: 10545379
The origins of clot rheological behavior associated with network morphology and factor XIIIa-induced cross-linking were studied in fibrin clots. Network morphology was manipulated by varying the concentrations of fibrinogen, thrombin,...
14.
Murthy S, Lomasney J, Mak E, Lorand L
Proc Natl Acad Sci U S A
. 1999 Oct;
96(21):11815-9.
PMID: 10518533
The inositol phosphate hydrolyzing activity of human phospholipase Cdelta1 (PLCdelta1) is markedly inhibited when the enzyme is coexpressed with the human heart G(h)/transglutaminase (TG) in human embryonic kidney cells. Because...
15.
Lorand L, Velasco P, Murthy S, Lefebvre P, Green D
Blood
. 1999 Jan;
93(3):909-17.
PMID: 9920840
Without a prior history of hemorrhagic disease, a 62-year-old man suffered recurrent episodes of bleeding. Solubility of the patient's clot in 5 mol/L urea indicated a problem with fibrin stabilization....
16.
Murthy S, Wilson J, Lukas T, Kuret J, Lorand L
J Neurochem
. 1998 Dec;
71(6):2607-14.
PMID: 9832162
A portion of the neurofibrillary tangles of Alzheimer's disease has the characteristics of cross-linked protein. Because the principal component of these lesions is the microtubule-associated protein tau, and because a...
17.
18.
Murthy S, Velasco P, Lorand L
Exp Eye Res
. 1998 Oct;
67(3):273-81.
PMID: 9778408
On account of its protein crosslinking activity, the Ca2+-dependent transglutaminase of the lens is likely to be involved in the formation of cataracts. We have now purified the rabbit lens...
19.
Lorand L, Stern A, Velasco P
Exp Eye Res
. 1998 Jun;
66(5):531-6.
PMID: 9628800
Post-translational modifications by transglutaminase may contribute to the remodeling of cellular architecture in the development of lens fiber cells, and there is evidence that the enzyme may also play a...
20.
Clement S, Velasco P, Murthy S, Wilson J, Lukas T, Goldman R, et al.
J Biol Chem
. 1998 Apr;
273(13):7604-9.
PMID: 9516464
Mere addition of Ca2+ to a lens cortical homogenate (bovine) generates a series of products composed of a variety of high molecular weight vimentin species. The Ca2+-induced cross-linking of this...