L H Kligman
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Explore the profile of L H Kligman including associated specialties, affiliations and a list of published articles.
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64
Citations
462
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Recent Articles
1.
Degwert J, Steckel F, Hoppe U, Kligman L
Toxicol In Vitro
. 2010 Jul;
11(5):613-8.
PMID: 20654359
Dendritic cells (DC) are highly specialized antigen-presenting cells (APC) located in many non-lymphoid tissues and a specialized form of DC-the Langerhans cell (LC)-is found in the skin. The functionality of...
2.
Basu A, Kligman L, Samulewicz S, HOWE C
BMC Cell Biol
. 2001 Sep;
2:15.
PMID: 11532190
Background: SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound...
3.
Kligman L, Elenitsas R
Melanoma Res
. 2001 Aug;
11(4):319-24.
PMID: 11479419
Melanomas have been induced in hamsters and guinea pigs with short-term, low dose applications of dimethylbenz [a]anthracene (DMBA) alone. In mice, however, melanoma induction has required either croton oil or...
4.
Kligman L, Schwartz E, Sapadin A, Kligman A
Photodermatol Photoimmunol Photomed
. 2000 Nov;
16(5):224-8.
PMID: 11068862
It is well known that photoaged skin is characterized by increases in dermal matrix components that include glycosaminoglycans, proteoglycans and masses of abnormal elastic fibers accompanied by substantial collagen loss....
5.
Kligman L, Yang S, Schwartz E
Photodermatol Photoimmunol Photomed
. 1999 Nov;
15(5):198-204.
PMID: 10540944
We have proposed that UV activation of cytokine and integrin signaling pathways may initiate the photoaging process and that one of the effects of tretinoin treatment may be to alter...
6.
Tavakkol A, Kligman L, Morrison Jr B, Polefka T
Contact Dermatitis
. 1998 Dec;
39(5):231-9.
PMID: 9840259
Laboratory tests to assess the irritant potential of materials, such as skin cleansers, which are normally used over a long period by humans, fail to mimic actual use. Most washing...
7.
Kligman A, Kligman L
Food Chem Toxicol
. 1998 Sep;
36(9-10):867-78.
PMID: 9737434
An enormous number of synthetic chemicals are incorporated in topical drugs, cosmetics and toiletries. These have the potential to cause irritant reactions when chronically applied to human skin. In predictive...
8.
Schwartz E, Gelfand J, Mauch J, Kligman L
Biochem Biophys Res Commun
. 1998 May;
246(1):217-21.
PMID: 9600095
The goal of this research was to delineate the post-transcriptional mechanisms responsible for the increased elastin synthesis characteristic of sundamaged skin. In this study, a unique molecular variant of the...
9.
Schwartz E, Sapadin A, Kligman L
Arch Dermatol Res
. 1998 Apr;
290(3):137-44.
PMID: 9558489
Chronically sun-damaged human skin has a wrinkled, aged appearance as a result of alterations in the dermal extracellular matrix. Secondary effectors such as cytokines and integrins may mediate the effects...
10.
Kligman L, Crosby M
Cancer Lett
. 1996 Oct;
107(2):217-22.
PMID: 8947516
The role of retinoids in hairless mouse photocarcinogenesis has been studied extensively but remains controversial. By contrast, the role of corticosteroids has hardly been investigated. Many findings indicate an antagonism...