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L Gardossi

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Citations 113
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Recent Articles
1.
Ferrario V, Braiuca P, Tessaro P, Knapic L, Gruber C, Pleiss J, et al.
J Biomol Struct Dyn . 2012 May; 30(1):74-88. PMID: 22571434
The mechanism and substrate specificity of alkanesulfonate monooxygenase (SsuD) was investigated by combining molecular dynamics simulations, docking, and a comprehensive quantitative structure activity relationships (QSAR) analysis. The FMNH(2) dependent monooxygenase...
2.
Braiuca P, Khaliullin I, Svedas V, Knapic L, Fermeglia M, Halling P, et al.
Biotechnol Bioeng . 2012 Jan; 109(7):1864-8. PMID: 22252881
Many enzymatic reactions are near-equilibrium reactions. This often limits final yield and hence application of biocatalyzed processes in the industrial production. The most widely applied strategy to overcome this issue...
3.
Chiaruttini C, Vicario A, Li Z, Baj G, Braiuca P, Wu Y, et al.
Proc Natl Acad Sci U S A . 2009 Oct; 106(38):16481-6. PMID: 19805324
Alternatively spliced brain-derived neurotrophic factor (BDNF) transcripts are targeted to distinct cellular compartments in neurons but the mechanisms underlying this sorting are unknown. Although only some BDNF isoforms are targeted...
4.
Boccu E, Ebert C, Gardossi L, Gianferrara T, Zacchigna M, Linda P
Farmaco . 1991 Apr; 46(4):565-77. PMID: 1930553
Statistical methods of optimization were applied to the enzymatic semisynthesis of ampicillin catalyzed by penicillin acylase. Since the traditional approach fails in determining both the presence of interactions between the...
5.
Boccu E, Ebert C, Gardossi L, Gianferrara T, Linda P
Biotechnol Bioeng . 1990 Apr; 35(9):928-34. PMID: 18592597
The stereoselective reduction of ethyl acetoacetate to (+)-(S)-ethyl 3-hydroxybutyrate catalyzed by Saccharomyces cerevisiae was optimized by means of chemometric methods. The quantitative effects of temperature, time of incubation, and concentrations...
6.
Boccu E, Gianferrara T, Gardossi L, Veronese F
Farmaco . 1990 Feb; 45(2):203-14. PMID: 2133995
Penicillin acylase (EC 3.5.1.11) from E. coli, both in solution and immobilized on solid supports, has been commercially exploited for the large scale production of 6-aminopenicillanic acid (6-APA), which is...