L F Povirk
Overview
Explore the profile of L F Povirk including associated specialties, affiliations and a list of published articles.
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67
Citations
1057
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Recent Articles
1.
Jones K, Elmore L, Jackson-Cook C, Demasters G, Povirk L, Holt S, et al.
Int J Radiat Biol
. 2005 Nov;
81(6):445-58.
PMID: 16308915
Ionizing radiation has been reported to promote accelerated or premature senescence in both normal and tumour cell lines. The current studies were designed to characterize the accelerated senescence response to...
2.
Chen S, Inamdar K, Pfeiffer P, Feldmann E, Hannah M, Yu Y, et al.
J Biol Chem
. 2001 Apr;
276(26):24323-30.
PMID: 11309379
To examine determinants of fidelity in DNA end joining, a substrate containing a model of a staggered free radical-mediated double-strand break, with cohesive phosphoglycolate-terminated 3'-overhangs and a one-base gap in...
3.
Chen S, Hannis J, Flora J, Muddiman D, Charles K, Yu Y, et al.
Anal Biochem
. 2001 Feb;
289(2):274-80.
PMID: 11161322
Single- and double-strand breaks bearing 3'-phosphoglycolate termini are among the most frequent lesions formed in DNA by ionizing radiation and other oxidative mutagens. In order to obtain homogeneous preparations of...
4.
Patteson K, Wang P, Povirk L
Cancer Res
. 1999 Aug;
59(15):3682-8.
PMID: 10446982
Previous work showed that the DNA double-strand cleaving agents bleomycin and neocarzinostatin were more mutagenic in plateau-phase than in log-phase cells. To determine whether topoisomerase II poisons that produce double-strand...
5.
Vrana J, Kramer L, Saunders A, Zhang X, Dent P, Povirk L, et al.
Biochem Pharmacol
. 1999 Jul;
58(1):121-31.
PMID: 10403525
Events accompanying sequential exposure of U937 leukemic cells to the deoxycytidine (dCyd) analogs 1-[beta-D-arabinofuranosyl]cytosine (ara-C) or 2',2'-difluorodeoxycytidine (gemcitabine; dFdC) followed by two protein kinase C (PKC) activators [bryostatin 1 (BRY)...
6.
Charles K, Povirk L
Chem Res Toxicol
. 1998 Dec;
11(12):1580-5.
PMID: 9860504
Bleomycin-induced cleavage was examined in several nicked, gapped, or intact duplex DNA substrates, including a structure designed to mimic a proposed singly nicked intermediate in double-strand cleavage. This nicked structure...
7.
Povirk L
Int J Radiat Biol
. 1998 Dec;
74(5):561-4.
PMID: 9848274
Molecular analysis of a bleomycin-induced rearrangement of the aprt gene in CHO cells revealed that it consisted of a nearly perfect three-way exchange among non-homologous sequences, consistent with a mechanism...
8.
Gu X, Weinfeld M, Povirk L
Biochemistry
. 1998 Jul;
37(27):9827-35.
PMID: 9657696
Previous work with Xenopus egg extracts suggested that a wortmannin-sensitive protein phosphorylation event precedes both the removal of modified termini from DNA double-strand break ends and the joining of unmodified...
9.
Charles K, Bauer G, Povirk L
Environ Mol Mutagen
. 1998 Jul;
31(4):333-9.
PMID: 9654242
Previous work showed that a CTAAA sequence in the supF gene of the shuttle plasmid pZ189 was a hotspot for mutagenesis by the aromatic nitrogen mustards melphalan and chlorambucil, and...
10.
Zhou R, Wang P, Zou Y, Jackson-Cook C, Povirk L
Cancer Res
. 1997 Nov;
57(21):4699-702.
PMID: 9354424
Among the aprt mutations induced in confluence-arrested Chinese hamster ovary D422 cells by the topoisomerase II poison amsacrine, there was a reciprocal exchange between the aprt gene and an unrelated...