L F Morton
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Explore the profile of L F Morton including associated specialties, affiliations and a list of published articles.
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30
Citations
751
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Recent Articles
1.
Knight C, Morton L, Peachey A, Tuckwell D, Farndale R, Barnes M
J Biol Chem
. 2000 Jan;
275(1):35-40.
PMID: 10617582
We have previously assigned an integrin alpha(2)beta(1)-recognition site in collagen I to the sequence, GFOGERGVEGPOGPA (O = Hyp), corresponding to residues 502-516 of the alpha(1)(I) chain and located in the...
2.
Verkleij M, Ijsseldijk M, Heijnen-Snyder G, Huizinga E, Morton L, Knight C, et al.
Thromb Haemost
. 1999 Sep;
82(3):1137-44.
PMID: 10494778
Seven overlapping peptides derived from the bovine alpha1(III)CB4 fragment of collagen III support static platelet adhesion, and an integrin alpha2beta1-recognition site has been assigned within this fragment to residues 522-528...
3.
Knight C, Morton L, Onley D, Peachey A, Ichinohe T, Okuma M, et al.
Cardiovasc Res
. 1999 May;
41(2):450-7.
PMID: 10341844
Objective: Peptides consisting of a repeat Gly-Pro-Hyp sequence are potent platelet agonists. The aim of this study was: (1) to examine the specificity of this sequence for platelet activation; (2)...
4.
Knight C, Morton L, Onley D, Peachey A, Messent A, Smethurst P, et al.
J Biol Chem
. 1998 Dec;
273(50):33287-94.
PMID: 9837901
The collagen type I-derived fragment alpha1(I)CB3 is known to recognize the platelet collagen receptor integrin alpha2beta1 as effectively as the parent collagen, although it lacks platelet-aggregatory activity. We have synthesized...
5.
Verkleij M, Morton L, Knight C, de Groot P, Barnes M, Sixma J
Blood
. 1998 Jun;
91(10):3808-16.
PMID: 9573018
The aim of this study was to define the need for specific collagen sequences and the role of their conformation in platelet adhesion to collagen under both static and flow...
6.
Morton L, Peachey A, Knight C, Farndale R, Barnes M
J Biol Chem
. 1997 Apr;
272(17):11044-8.
PMID: 9110997
The platelet-reactive collagen III-derived fragment alpha1(III)CB4 has been synthesized as seven overlapping peptides, each as a homotrimeric triple-helical species covalently linked at the C terminus. Additional Gly-Pro-Hyp triplets were introduced...
7.
Asselin J, Gibbins J, Achison M, Lee Y, Morton L, Farndale R, et al.
Blood
. 1997 Feb;
89(4):1235-42.
PMID: 9028946
Activation of platelets by collagen is mediated through a tyrosine kinase-dependent pathway that is associated with phosphorylation of the Fc receptor gamma chain, the tyrosine kinase syk, and phospholipase C...
8.
Saklatvala J, Rawlinson L, Waller R, Sarsfield S, Lee J, Morton L, et al.
J Biol Chem
. 1996 Mar;
271(12):6586-9.
PMID: 8636072
p38 mitogen-activated protein kinase (MAPK) was identified in platelets on the basis of (a) its reactivity with antibodies to C-terminal and N-terminal peptides, and (b) its ability to activate MAPK-activated...
9.
Morton L, Hargreaves P, Farndale R, Young R, Barnes M
Biochem J
. 1995 Mar;
306 ( Pt 2):337-44.
PMID: 7534064
The platelet reactivities of two simple collagen-like synthetic peptides, Gly-Lys-Hyp-(Gly-Pro-Hyp)10-Gly-Lys-Hyp-Gly and Gly-Cys-Hyp-(Gly-Pro-Hyp)10-Gly-Cys-Hyp-Gly, were investigated. Both peptides adopted a stable triple-helical conformation in solution. Following cross-linking, both peptides proved to be...
10.
Morton L, Peachey A, Zijenah L, Goodall A, Humphries M, Barnes M
Biochem J
. 1994 May;
299 ( Pt 3):791-7.
PMID: 7514871
Platelet adhesion has been measured to type-I monomeric collagen, collagen fibres, alpha 1(I) and alpha 2(I) chains and the chain fragments alpha 1(I)CB3, alpha 1(I)CB6, alpha 1(I)CB7 and alpha 1(I)CB8,...