L E Orgel
Overview
Explore the profile of L E Orgel including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
218
Citations
5135
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kozlov I, Politis P, Van Aerschot A, Busson R, Herdewijn P, Orgel L
J Am Chem Soc
. 2001 Sep;
121(12):2653-6.
PMID: 11543583
Hexitol nucleic acid (HNA) is an analogue of DNA containing the standard nucleoside bases, but with a phosphorylated 1,5-anhydrohexitol backbone. HNA oligomers form duplexes having the nucleic acid A structure...
2.
Kozlov I, Orgel L
Helv Chim Acta
. 2001 Sep;
82(11):1799-805.
PMID: 11543571
The template-directed oligomerization of nucleoside-5'-phosphoro-2-methyl imidazolides on standard oligonucleotide templates has been studied extensively. Here, we describe experiments with templates in which inosinic acid (I) is substituted for guanylic acid,...
3.
Zielinski M, Kozlov I, Orgel L
Helv Chim Acta
. 2001 Sep;
83(8):1678-84.
PMID: 11543568
Nonenzymatic template-directed copying of RNA sequences rich in cytidylic acid using nucleoside 5'-(2-methylimidazol-1-yl phosphates) as substrates is substantially more efficient than the copying of corresponding DNA sequences. However, many sequences...
4.
Kozlov I, De Bouvere B, Van Aerschot A, Herdewijn P, Orgel L
J Am Chem Soc
. 2001 Sep;
121(25):5856-9.
PMID: 11542282
Hexitol nucleic acids (HNAs) are DNA analogues that contain the standard nucleoside bases attached to a phosphorylated 1,5-anhydrohexitol backbone. We find that HNAs support efficient information transfer in nonensymatic template-directed...
5.
Koppitz M, Nielsen P, Orgel L
J Am Chem Soc
. 2001 Sep;
120(19):4563-9.
PMID: 11541746
DNA sequences have previously been reported to act as templates for the synthesis of PNA, and vice versa. A continuous evolutionary transition from an informational replicating system based on one...
6.
Kozlov I, Politis P, Pitsch S, Herdewijn P, Orgel L
J Am Chem Soc
. 2001 Sep;
121(5):1108-9.
PMID: 11541447
No abstract available.
7.
8.
Orgel L
Orig Life Evol Biosph
. 2001 Sep;
28(1):91-6.
PMID: 11536858
We do not understand the steps leading from the abiotic early earth to the RNA world. Consequently, we cannot estimate the time required for the origins of life. Attempts to...
9.
Liu R, Orgel L
Orig Life Evol Biosph
. 2001 Sep;
28(1):47-60.
PMID: 11536855
We have compared carbonyl diimidazole (CDI) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC) as activating agents for the oligomerization of negatively-charged alpha- and beta-amino acids in homogeneous aqueous solution. alpha-Amino acids can be...
10.
Wen K, Orgel L
Orig Life Evol Biosph
. 2001 Jul;
31(3):241-8.
PMID: 11434103
We have used amino acids activated by carbonyldiimidazole to study the enantiospecificity of peptide elongation in aqueous solution. Peptide 'primers' Glu10 and Ala3Glu10 were elongated with the enantiomers of arginine,...