L Covic
Overview
Explore the profile of L Covic including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
289
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0
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Recent Articles
1.
Yang E, Cisowski J, Nguyen N, OCallaghan K, Xu J, Agarwal A, et al.
Oncogene
. 2015 Jul;
35(12):1529-40.
PMID: 26165842
As the majority of patients with basal-like breast carcinoma present with invasive, metastatic disease that do not respond to available therapies, it is essential to identify new therapeutic targets that...
2.
Foley C, Fanjul-Fernandez M, Bohm A, Nguyen N, Agarwal A, Austin K, et al.
Oncogene
. 2013 May;
33(17):2264-72.
PMID: 23708660
Matrix metalloprotease-1 (MMP1) is an important mediator of tumorigenesis, inflammation and tissue remodeling through its ability to degrade critical matrix components. Recent studies indicate that stromal-derived MMP1 may exert direct...
3.
Michael E, Kuliopulos A, Covic L, Steer M, Perides G
Am J Physiol Gastrointest Liver Physiol
. 2013 Jan;
304(5):G516-26.
PMID: 23275617
Pancreatic acinar cells express proteinase-activated receptor-2 (PAR2) that is activated by trypsin-like serine proteases and has been shown to exert model-specific effects on the severity of experimental pancreatitis, i.e., PAR2(-/-)...
4.
Covic L, Gresser A, Kuliopulos A
Biochemistry
. 2000 May;
39(18):5458-67.
PMID: 10820018
Thrombin activates platelets in an ordered sequence of events that includes shape change, increase in cytoplasmic Ca(2+), activation of the alphaIIbbeta3 integrin, granule secretion, aggregation, and formation of a stable...
5.
Swift S, Sheridan P, Covic L, Kuliopulos A
J Biol Chem
. 2000 Jan;
275(4):2627-35.
PMID: 10644723
Signal transfer between the protease-activated PAR1 thrombin receptor and membrane-associated heterotrimeric G proteins is mediated by protein-protein interactions. We constructed a yeast signaling system that resolves domain-specific functions of binding...
6.
Covic L, Silva N, Lew R
Biochim Biophys Acta
. 1999 Nov;
1451(2-3):242-54.
PMID: 10556579
The Arabidopsis thaliana ARAKIN (ATMEKK1) gene shows strong homology to members of the (MAP) mitogen-activated protein kinase family, and was previously shown to functionally complement a mating defect in Saccharomyces...
7.
Kuliopulos A, Covic L, Seeley S, Sheridan P, Helin J, Costello C
Biochemistry
. 1999 Apr;
38(14):4572-85.
PMID: 10194379
It has been hypothesized that protease-activated receptors may be activated and attenuated by more than one protease. Here, we explore a desensitization mechanism of the PAR1 thrombin receptor by anticoagulant...
8.
Covic L, Lew R
Biochim Biophys Acta
. 1996 Mar;
1305(3):125-9.
PMID: 8597596
The yeast Saccharomyces cerevisiae ste6 mutant is defective in transport of a-mating factor, resulting in an inability of ste6 a cells to mate with alpha cells. The gene encodes an...
9.
Lew R, Garrill A, Covic L, Heath I, Serlin B
FEBS Lett
. 1992 Oct;
310(3):219-22.
PMID: 1397276
Protoplasts of the filamentous alga, Mougeotia, and the filamentous fungal oomycete, Saprolegnia ferax, exhibit two K+ ion channels (2-6 pA) using the patch-clamp technique when the seals are less than...
10.
Kaech S, Covic L, Wyss A, Ballmer-Hofer K
Nature
. 1991 Apr;
350(6317):431-3.
PMID: 1707141
Polyoma middle-T antigen is required for tumorigenesis in animals and for viral transformation of a variety of cells in culture (reviewed in ref. 1). Middle-T associates with and thereby activates...