L B Moran
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Explore the profile of L B Moran including associated specialties, affiliations and a list of published articles.
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16
Citations
562
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Recent Articles
1.
Slodzinski H, Moran L, Michael G, Wang B, Novoselov S, Cheetham M, et al.
Clin Neuropathol
. 2009 Oct;
28(5):333-43.
PMID: 19788048
Background: Recent studies highlight the role of endoplasmic reticulum (ER) stress and aberrant protein degradation in the pathogenesis of neurodegenerative disorders. Herp which is encoded by the HERPUD 1 (homocysteine-inducible,...
2.
Durrenberger P, Filiou M, Moran L, Michael G, Novoselov S, Cheetham M, et al.
J Neurosci Res
. 2008 Aug;
87(1):238-45.
PMID: 18711724
DnaJ/Hsp40 chaperones determine the activity of Hsp70s by stabilizing their interaction with substrate proteins. We have predicted, based on the in silico analysis of a brain-derived whole-genome transcriptome data set,...
3.
Kalaitzakis M, Christian L, Moran L, Graeber M, Pearce R, Gentleman S
Parkinsonism Relat Disord
. 2008 Jul;
15(3):196-204.
PMID: 18602855
The pathological basis of dementia and visual hallucinations in Parkinson's disease (PD) is not yet fully understood. To investigate this further we have conducted a clinico-pathological study based on 30...
4.
Duke D, Moran L, Pearce R, Graeber M
Neurogenetics
. 2007 Jan;
8(2):83-94.
PMID: 17211632
Sporadic Parkinson's disease (PD) is characterized by progressive death of dopaminergic neurons within the substantia nigra. However, pathological cell death within this nucleus is not uniform. In PD, the lateral...
5.
Moran L, Croisier E, Duke D, Kalaitzakis M, Roncaroli F, Deprez M, et al.
Acta Neuropathol
. 2007 Jan;
113(3):253-63.
PMID: 17203291
The identification of mutations that cause familial Parkinson's disease (PD) provides a framework for studies into pathways that may be perturbed also in the far more common, non-familial form of...
6.
Duke D, Moran L, Kalaitzakis M, Deprez M, Dexter D, Pearce R, et al.
Neurogenetics
. 2006 May;
7(3):139-48.
PMID: 16699787
There is growing evidence that dysfunction of the mitochondrial respiratory chain and failure of the cellular protein degradation machinery, specifically the ubiquitin-proteasome system, play an important role in the pathogenesis...
7.
Moran L, Duke D, Deprez M, Dexter D, Pearce R, Graeber M
Neurogenetics
. 2005 Dec;
7(1):1-11.
PMID: 16344956
We have used brain tissue from clinically well-documented and neuropathologically confirmed cases of sporadic Parkinson's disease to establish the transcriptomic expression profile of the medial and lateral substantia nigra. In...
8.
Duke D, Moran L, Turkheimer F, Banati R, Graeber M
Dev Neurosci
. 2004 Oct;
26(1):30-7.
PMID: 15509896
The cell culture model utilized in this study represents one of the most widely used paradigms of microglia in vitro. After 14 days, microglia harvested from the neonatal rat brain...
9.
Moran L, Duke D, Turkheimer F, Banati R, Graeber M
Neurogenetics
. 2004 Mar;
5(2):95-108.
PMID: 15042428
This study provides an expression signature of interferon-gamma (IFN-gamma)-activated microglia. Microglia are macrophage precursor cells residing in the brain and spinal cord. The microglial phenotype is highly plastic and changes...
10.
Moran L, Kosel S, Spitzer C, Schwaiger F, Riess O, Kreutzberg G, et al.
J Neurocytol
. 2002 May;
30(6):515-21.
PMID: 12037467
The discovery that missense mutations in the alpha-synuclein gene represent a rare genetic cause of Parkinson's disease (PD) has had significant impact on the development of research into neurodegenerative disorders....