L B Ivashkiv
Overview
Explore the profile of L B Ivashkiv including associated specialties, affiliations and a list of published articles.
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21
Citations
588
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Recent Articles
1.
Rogatsky I, Ivashkiv L
Tissue Antigens
. 2006 Jun;
68(1):1-12.
PMID: 16774534
Cytokine signaling is essential for intercellular communication and affects cell proliferation, differentiation, and survival. In the immune system, cytokines coordinate the activities of many cell types ultimately leading to both...
2.
Deon D, Ahmed S, Tai K, Scaletta N, Herrero C, Lee I, et al.
J Immunol
. 2001 Oct;
167(9):5395-403.
PMID: 11673558
The balance between pro- and anti-inflammatory cytokines plays an important role in determining the severity of inflammation in rheumatoid arthritis (RA). Antagonism between opposing cytokines at the level of signal...
3.
Meffre E, Davis E, Schiff C, Cunningham-Rundles C, Ivashkiv L, Staudt L, et al.
Nat Immunol
. 2001 Mar;
1(3):207-13.
PMID: 10973277
Immunoglobulin gene recombination can result in the assembly of self-reactive antibodies. Deletion, anergy or receptor editing normally silence B cells that produce these autoantibodies. Receptor editing is highly efficient in...
4.
Ivashkiv L
Rev Immunogenet
. 2001 Mar;
2(2):220-30.
PMID: 11258419
Many, if not most, cytokines important for immune responses utilize the Jak-STAT signaling pathway. Jaks are receptor-associated protein tyrosine kinases, and STATs are latent cytoplasmic transcription factors that are activated...
5.
Ahmed S, Ivashkiv L
J Immunol
. 2000 Oct;
165(9):5227-37.
PMID: 11046056
The development and resolution of an inflammatory process are regulated by a complex interplay among cytokines that have pro- and anti-inflammatory effects. Effective and sustained action of a proinflammatory cytokine...
6.
Bianchi M, Meng C, Ivashkiv L
Proc Natl Acad Sci U S A
. 2000 Aug;
97(17):9573-8.
PMID: 10920190
Glucocorticoids (GCs) are potent anti-inflammatory agents that block cytokine production. We investigated whether GCs also block cytokine signaling via the Janus kinase (Jak)-signal transducer and activator of transcription (STAT) pathway....
7.
Lee I, Li W, Hisert K, Ivashkiv L
J Exp Med
. 1999 Nov;
190(9):1263-74.
PMID: 10544198
Limitation of clonal expansion of activated T cells is necessary for immune homeostasis, and is achieved by growth arrest and apoptosis. Growth arrest and apoptosis can occur passively secondary to...
8.
Castro A, Sengupta T, RUIZ D, Yang E, Ivashkiv L
J Immunol
. 1999 Feb;
162(3):1261-9.
PMID: 9973378
IL-2 activates several distinct signaling pathways that are important for T cell activation, proliferation, and differentiation into both Th1 and Th2 phenotypes. IL-4, the major cytokine that promotes differentiation of...
9.
Sengupta T, Talbot E, Scherle P, Ivashkiv L
Proc Natl Acad Sci U S A
. 1998 Sep;
95(19):11107-12.
PMID: 9736697
Gene activation and cellular differentiation induced by interleukin-6 (IL-6) and transcription factor Stat3 are suppressed by several factors, including ionomycin, granulocyte/macrophage-colony-stimulating factor, and phorbol 12-myristate 13-acetate (PMA), that block IL-6-induced...
10.
Sengupta T, Schmitt E, Ivashkiv L
Proc Natl Acad Sci U S A
. 1996 Sep;
93(18):9499-504.
PMID: 8790359
An important component of cytokine regulation of cell growth and differentiation is rapid transcriptional activation of genes by the JAK-STAT (signal transducer and activator of transcription) signaling pathway. Ligation of...