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L Aravind

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Articles 415
Citations 41851
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Recent Articles
1.
Sivakumar P, Pandey S, Ramesha A, Davda J, Singh A, Kumar C, et al.
Nat Plants . 2025 Mar; PMID: 40087543
Plants alternate between diploid sporophyte and haploid gametophyte generations. In mosses, which retain features of ancestral land plants, the gametophyte is dominant and has an independent existence. However, in flowering...
2.
Liu H, Iyer L, Norris P, Liu R, Yu K, Grant M, et al.
Nat Plants . 2025 Mar; PMID: 40033073
No abstract available.
3.
Liu H, Iyer L, Norris P, Liu R, Yu K, Grant M, et al.
Nat Plants . 2025 Feb; 11(2):263-278. PMID: 39953358
Dietary consumption of lysine in humans leads to the biosynthesis of Δ-piperideine-6-carboxylic acid (P6C), with elevated levels linked to the neurological disorder epilepsy. Here we demonstrate that P6C biosynthesis is...
4.
Campbell A, Esser H, Burroughs A, Berninghausen O, Aravind L, Becker T, et al.
Mol Cell . 2025 Feb; 85(5):999-1007.e7. PMID: 39922193
Although many antibiotics inhibit bacterial ribosomes, the loss of known factors that rescue stalled ribosomes does not lead to robust antibiotic sensitivity in E. coli, suggesting the existence of additional...
5.
Zamba-Campero M, Soliman D, Yu H, Lasseter A, Chang Y, Silberman J, et al.
Nat Commun . 2024 Nov; 15(1):10417. PMID: 39614093
Flagella propel pathogens through their environments, yet are expensive to synthesize and are immunogenic. Thus, complex hierarchical regulatory networks control flagellar gene expression. Spirochetes are highly motile bacteria, but peculiarly,...
6.
Kahne S, Yoo J, Chen J, Nakedi K, Iyer L, Putzel G, et al.
Proc Natl Acad Sci U S A . 2024 Nov; 121(49):e2407239121. PMID: 39585979
In , proteins that are posttranslationally modified with a prokaryotic ubiquitin-like protein (Pup) can be degraded by bacterial proteasomes. A single Pup-ligase and depupylase shape the pupylome, but the mechanisms...
7.
Ma M, Dubey R, Jen A, Pusapati G, Singal B, Shishkova E, et al.
Science . 2024 Nov; 386(6722):667-672. PMID: 39509507
One-fifth of human proteins are N-glycosylated in the endoplasmic reticulum (ER) by two oligosaccharyltransferases, OST-A and OST-B. Contrary to the prevailing view of N-glycosylation as a housekeeping function, we identified...
8.
Ramos-Leon F, Anjuwon-Foster B, Anantharaman V, Updegrove T, Ferreira C, Ibrahim A, et al.
Nat Microbiol . 2024 Oct; 9(11):2997-3012. PMID: 39468247
The bacterial pathogen, Staphylococcus aureus, grows by dividing in two alternating orthogonal planes. How these cell division planes are positioned correctly is not known. Here we used chemical genetic screening...
9.
Updegrove T, Delerue T, Anantharaman V, Cho H, Chan C, Nipper T, et al.
Sci Adv . 2024 Oct; 10(42):eadq0791. PMID: 39423260
Starvation triggers bacterial spore formation, a committed differentiation program that transforms a vegetative cell into a dormant spore. Cells in a population enter sporulation nonuniformly to secure against the possibility...
10.
Delerue T, Updegrove T, Chareyre S, Anantharaman V, Gilmore M, Jenkins L, et al.
Proc Natl Acad Sci U S A . 2024 Oct; 121(43):e2414737121. PMID: 39405354
spores are produced inside the cytosol of a mother cell. Spore surface assembly requires the SpoVK protein in the mother cell, but its function is unknown. Here, we report that...