L A ONeill
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Explore the profile of L A ONeill including associated specialties, affiliations and a list of published articles.
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78
Citations
2604
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Recent Articles
1.
Kammoun H, Allen T, Henstridge D, Barre S, Coll R, Lancaster G, et al.
Mol Metab
. 2018 Feb;
10:66-73.
PMID: 29478918
Objectives: Type 2 diabetes (T2D) is associated with chronic, low grade inflammation. Activation of the NLRP3 inflammasome and secretion of its target interleukin-1β (IL-1β) have been implicated in pancreatic β...
2.
Bernard N, Finlay C, Tannahill G, Cassidy J, ONeill L, Mills K
Mucosal Immunol
. 2014 Dec;
8(5):982-92.
PMID: 25515629
Bordetella pertussis causes whooping cough, an infectious disease of the respiratory tract that is re-emerging despite high vaccine coverage. Here we examined the role of Toll-like receptor (TLR) adapter protein...
3.
ONeill L
Sci STKE
. 2001 Dec;
2000(44):re1.
PMID: 11752602
The signal transduction pathways activated by the proinflammatory cytokine interleukin-1 (IL-1) have been the focus of much attention because of the important role that IL-1 plays in inflammatory diseases. A...
4.
Mansell A, Reinicke A, Worrall D, ONeill L
FEBS Lett
. 2001 Dec;
508(3):313-7.
PMID: 11728442
In Drosophila, the Toll family of proteins mediates the innate immune response. Toll is activated by Spaetzle, which is generated in response to pathogens via a serine protease cascade. We...
5.
Kelly A, Lynch A, Vereker E, Nolan Y, Queenan P, Whittaker E, et al.
J Biol Chem
. 2001 Oct;
276(49):45564-72.
PMID: 11581275
Several effects of the proinflammatory cytokine, interleukin-1 beta (IL-1 beta), have been described in the central nervous system, and one area of the brain where marked changes have been reported...
6.
Dunn E, Sims J, Nicklin M, ONeill L
Trends Immunol
. 2001 Sep;
22(10):533-6.
PMID: 11574261
No abstract available.
7.
Mansell A, Khelef N, Cossart P, ONeill L
J Biol Chem
. 2001 Sep;
276(47):43597-603.
PMID: 11571285
Internalin B (InlB), a 630-amino acid protein loosely attached to the surface of Listeria monocytogenes, participates in the entry of the bacterium into mammalian cells. This process requires the activation...
8.
Fitzgerald K, Palsson-McDermott E, Bowie A, Jefferies C, Mansell A, Brady G, et al.
Nature
. 2001 Sep;
413(6851):78-83.
PMID: 11544529
The recognition of microbial pathogens by the innate immune system involves Toll-like receptors (TLRs), which recognize pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns, with TLR-4 mediating the...
9.
Jefferies C, Bowie A, Brady G, Cooke E, Li X, ONeill L
Mol Cell Biol
. 2001 Jun;
21(14):4544-52.
PMID: 11416133
We have examined the involvement of components of the interleukin-1 (IL-1) signaling pathway in the transactivation of gene expression by the p65 subunit of NF-kappaB. Transient transfection of cells with...
10.
Mansell A, Braun L, Cossart P, ONeill L
Cell Microbiol
. 2001 Feb;
2(2):127-36.
PMID: 11207569
Listeria monocytogenes causes a pro-inflammatory response on adhesion to macrophages. Upregulation of inflammation genes involves the transcription factor NF-kappaB. Several components of L. monocytogenes, including lipoteichoic acid (LTA), phospholipases and...