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Kyungho Chang

Explore the profile of Kyungho Chang including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 17
Citations 294
Followers 0
Related Specialties
Anesthesiology
Critical Care
Cell Biology
Top 10 Co-Authors
Yoshitsugu Yamada
Masao Kaneki
Kanji Uchida
Nobuyuki Shimizu
Shohei Shinozaki
Masahiko Bougaki
Ken Kuwajima
Takahiro Hiruma
Yoshiro Yamamura
Harumasa Nakazawa
Published In
Masui
Crit Care Med
J Pharmacol Exp Ther
Sci Signal
Am J Respir Cell Mol Biol
Affiliations
Soon will be listed here.
Recent Articles
1.
Successful treatment of bepridil-induced intraoperative torsades de pointes by isoproterenol infusion
Shimano K, Chang K, Hara Y, Yasuda A, Sawamura S
JA Clin Rep . 2021 Oct; 7(1):76. PMID: 34643822
Background: Several types of antiarrhythmic drugs are known to induce QT prolongation and torsades de pointes. Case Presentation: An 84-year-old man was scheduled for open gastrectomy for residual cancer. He...
2.
A retrospective review of 10-year trends in general anesthesia for cesarean delivery at a university hospital: the impact of a newly launched team on obstetric anesthesia practice
Ikeda T, Kato A, Bougaki M, Araki Y, Ohata T, Kawashima S, et al.
BMC Health Serv Res . 2020 May; 20(1):421. PMID: 32404093
Background: The indications for general anesthesia (GA) in obstetric settings, which are determined in consideration of maternal and fetal outcome, could be affected by local patterns of clinical practice grounded...
3.
Synergistic cytoprotection by co-treatment with dexamethasone and rapamycin against proinflammatory cytokine-induced alveolar epithelial cell injury
Kuwajima K, Chang K, Furuta A, Bougaki M, Uchida K, Sawamura S, et al.
J Intensive Care . 2019 Feb; 7:12. PMID: 30774959
Background: One of the main pathophysiological manifestations during the acute phase of sepsis is massive production of proinflammatory mediators. Clinical trials involving direct suppression of inflammatory mediators to relieve organ...
4.
A Case of a Cardiac Resynchronization Therapy-Defibrillator Exhibiting a Lower and Alternately Variable Basic Rate
Iwazaki K, Kojima T, Murasawa T, Yokota J, Tanimoto H, Matsuda J, et al.
Int Heart J . 2018 Apr; 59(3):626-629. PMID: 29628471
A cardiac resynchronization therapy defibrillator (CRT-D) (Medtronic Inc. Protecta XT) was implanted in a 67-year-old man who had cardiac sarcoidosis with extremely low cardiac function. He had ventricular tachycardia which...
5.
Early-phase Innate Immune Suppression in Murine Severe Sepsis Is Restored with Systemic Interferon-β
Kusakabe Y, Uchida K, Yamamura Y, Hiruma T, Totsu T, Tamai Y, et al.
Anesthesiology . 2018 Mar; 129(1):131-142. PMID: 29601323
Background: Sepsis is a leading cause of death in the intensive care unit. Immune modulatory therapy targeting sepsis-associated proinflammatory responses has not shown survival benefit. Here, the authors evaluated innate...
6.
IFN-β Improves Sepsis-related Alveolar Macrophage Dysfunction and Postseptic Acute Respiratory Distress Syndrome-related Mortality
Hiruma T, Tsuyuzaki H, Uchida K, Trapnell B, Yamamura Y, Kusakabe Y, et al.
Am J Respir Cell Mol Biol . 2018 Jan; 59(1):45-55. PMID: 29365277
IFN-β is reported to improve survival in patients with acute respiratory distress syndrome (ARDS), possibly by preventing sepsis-induced immunosuppression, but its therapeutic nature in ARDS pathogenesis is poorly understood. We...
7.
Development of a local anesthetic lidocaine-loaded redox-active injectable gel for postoperative pain management
Nagasaki Y, Mizukoshi Y, Gao Z, Feliciano C, Chang K, Sekiyama H, et al.
Acta Biomater . 2017 May; 57:127-135. PMID: 28457963
Statement Of Significance: 1. We have been working on nanomaterials, which effectively eliminate ROS, avoiding dysfunction of mitochondria in healthy cells. 2. We designed redox injectable gel using polyion complexed...
8.
iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53
Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, et al.
PLoS One . 2017 Jan; 12(1):e0170391. PMID: 28099528
Inflammation and apoptosis develop in skeletal muscle after major trauma, including burn injury, and play a pivotal role in insulin resistance and muscle wasting. We and others have shown that...
9.
Inflammatory stimuli induce inhibitory S-nitrosylation of the deacetylase SIRT1 to increase acetylation and activation of p53 and p65
Shinozaki S, Chang K, Sakai M, Shimizu N, Yamada M, Tanaka T, et al.
Sci Signal . 2014 Nov; 7(351):ra106. PMID: 25389371
Inflammation increases the abundance of inducible nitric oxide synthase (iNOS), leading to enhanced production of nitric oxide (NO), which can modify proteins by S-nitrosylation. Enhanced NO production increases the activities...
10.
iNOS inhibitor, L-NIL, reverses burn-induced glycogen synthase kinase-3β activation in skeletal muscle of rats
Kaneki M, Fukushima Y, Shinozaki S, Fukaya M, Habiro M, Shimizu N, et al.
Metabolism . 2012 Sep; 62(3):341-6. PMID: 22995863
Objectives: Recent studies suggest that activation of glycogen synthase kinase (GSK)-3β may be involved in burn injury-induced metabolic derangements and protein breakdown in skeletal muscle. However, the mechanism for GSK-3β...