Kyo-Ichi Isono
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Explore the profile of Kyo-Ichi Isono including associated specialties, affiliations and a list of published articles.
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18
Citations
1873
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Recent Articles
1.
Dong Y, Isono K, Ohbo K, Endo T, Ohara O, Maekawa M, et al.
Mol Cell Biol
. 2017 Jul;
37(19).
PMID: 28694333
Global histone hyperacetylation is suggested to play a critical role for replacement of histones by transition proteins and protamines to compact the genome during spermiogenesis. However, the underlying mechanisms for...
2.
Dewi V, Kwok A, Lee S, Lee M, Tan Y, Nicholas H, et al.
J Biol Chem
. 2015 Feb;
290(13):8591-605.
PMID: 25659434
Krüppel-like factor 3 (KLF3/BKLF), a member of the Krüppel-like factor (KLF) family of transcription factors, is a widely expressed transcriptional repressor with diverse biological roles. Although there is considerable understanding...
3.
Koike H, Ueno Y, Naito T, Shiina T, Nakata S, Ouchi R, et al.
Hepatology
. 2014 Feb;
60(1):323-33.
PMID: 24497168
Unlabelled: Polycomb-group (PcG) proteins play crucial roles in self-renewal of stem cells by suppressing a host of genes through histone modifications. Identification of the downstream genes of PcG proteins is...
4.
Choi D, Na W, Kabir M, Yi E, Kwon S, Yeom J, et al.
Mol Cell
. 2013 Jul;
51(3):374-85.
PMID: 23871434
WIP1 (wild-type p53-induced phosphatase 1) functions as a homeostatic regulator of the ataxia telangiectasia mutated (ATM)-mediated signaling pathway in response to ionizing radiation (IR). Here we identify homeodomain-interacting protein kinase...
5.
Endoh M, Endo T, Endoh T, Isono K, Sharif J, Ohara O, et al.
PLoS Genet
. 2012 Jul;
8(7):e1002774.
PMID: 22844243
Two distinct Polycomb complexes, PRC1 and PRC2, collaborate to maintain epigenetic repression of key developmental loci in embryonic stem cells (ESCs). PRC1 and PRC2 have histone modifying activities, catalyzing mono-ubiquitination...
6.
Li X, Isono K, Yamada D, Endo T, Endoh M, Shinga J, et al.
Mol Cell Biol
. 2010 Nov;
31(2):351-64.
PMID: 21059868
The Polycomb group of proteins forms at least two distinct complexes designated the Polycomb repressive complex-1 (PRC1) and PRC2. These complexes cooperate to mediate transcriptional repression of their target genes,...
7.
Puschendorf M, Terranova R, Boutsma E, Mao X, Isono K, Brykczynska U, et al.
Nat Genet
. 2008 Mar;
40(4):411-20.
PMID: 18311137
In eukaryotes, Suv39h H3K9 trimethyltransferases are required for pericentric heterochromatin formation and function. In early mouse preimplantation embryos, however, paternal pericentric heterochromatin lacks Suv39h-mediated H3K9me3 and downstream marks. Here we...
8.
de la Cruz C, Kirmizis A, Simon M, Isono K, Koseki H, Panning B
Chromosome Res
. 2007 Apr;
15(3):299-314.
PMID: 17406994
Regulation of histone methylation is critical for proper gene expression and chromosome function. Suppressor of Zeste 12 (SUZ12) is a requisite member of the EED/EZH2 histone methyltransferase complexes, and is...
9.
Miyake Y, Kaise H, Isono K, Koseki H, Kohno K, Tanaka M
J Immunol
. 2007 Apr;
178(8):5001-9.
PMID: 17404282
Macrophages have a wide variety of activities and it is largely unknown how the diverse phenotypes of macrophages contribute to pathological conditions in the different types of tissue injury in...
10.
Takada Y, Isono K, Shinga J, Turner J, Kitamura H, Ohara O, et al.
Development
. 2007 Jan;
134(3):579-90.
PMID: 17215307
The product of the Scmh1 gene, a mammalian homolog of Drosophila Sex comb on midleg, is a constituent of the mammalian Polycomb repressive complexes 1 (Prc1). We have identified Scmh1...