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Kyle W Karhohs

Explore the profile of Kyle W Karhohs including associated specialties, affiliations and a list of published articles. Areas
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Articles 12
Citations 1697
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Recent Articles
1.
Berryer M, Rizki G, Nathanson A, Klein J, Trendafilova D, Susco S, et al.
Elife . 2023 Apr; 12. PMID: 37083703
Resolving fundamental molecular and functional processes underlying human synaptic development is crucial for understanding normal brain function as well as dysfunction in disease. Based upon increasing evidence of species-divergent features...
2.
Boivin B, Roet K, Huang X, Karhohs K, Rohban M, Sandoe J, et al.
Mol Biol Cell . 2021 Dec; 33(6):ar54. PMID: 34910584
Patient stem cell-derived models enable imaging of complex disease phenotypes and the development of scalable drug discovery platforms. Current preclinical methods for assessing cellular activity do not, however, capture the...
3.
Tsabar M, Mock C, Venkatachalam V, Reyes J, Karhohs K, Oliver T, et al.
Cell Rep . 2020 Nov; 33(6):108392. PMID: 33176156
No abstract available.
4.
Tsabar M, Mock C, Venkatachalam V, Reyes J, Karhohs K, Oliver T, et al.
Cell Rep . 2020 Aug; 32(5):107995. PMID: 32755587
Cellular responses to stimuli can evolve over time, resulting in distinct early and late phases in response to a single signal. DNA damage induces a complex response that is largely...
5.
French S, Vijey P, Karhohs K, Wilkie A, Horin L, Ray A, et al.
J Thromb Haemost . 2020 Jul; 18(10):2701-2711. PMID: 32662223
Background: The mechanisms that regulate platelet biogenesis remain unclear; factors that trigger megakaryocytes (MKs) to initiate platelet production are poorly understood. Platelet formation begins with proplatelets, which are cellular extensions...
6.
Caicedo J, Goodman A, Karhohs K, Cimini B, Ackerman J, Haghighi M, et al.
Nat Methods . 2020 Jan; 17(2):241. PMID: 31969730
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
7.
Caicedo J, Goodman A, Karhohs K, Cimini B, Ackerman J, Haghighi M, et al.
Nat Methods . 2019 Oct; 16(12):1247-1253. PMID: 31636459
Segmenting the nuclei of cells in microscopy images is often the first step in the quantitative analysis of imaging data for biological and biomedical applications. Many bioimage analysis tools can...
8.
Caicedo J, Roth J, Goodman A, Becker T, Karhohs K, Broisin M, et al.
Cytometry A . 2019 Jul; 95(9):952-965. PMID: 31313519
Identifying nuclei is often a critical first step in analyzing microscopy images of cells and classical image processing algorithms are most commonly used for this task. Recent developments in deep...
9.
Reyes J, Chen J, Stewart-Ornstein J, Karhohs K, Mock C, Lahav G
Mol Cell . 2019 Mar; 73(6):1306. PMID: 30901565
No abstract available.
10.
Reyes J, Chen J, Stewart-Ornstein J, Karhohs K, Mock C, Lahav G
Mol Cell . 2018 Jul; 71(4):581-591.e5. PMID: 30057196
Biological signals need to be robust and filter small fluctuations yet maintain sensitivity to signals across a wide range of magnitudes. Here, we studied how fluctuations in DNA damage signaling...