Kyle R Salci
Overview
Explore the profile of Kyle R Salci including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
194
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Recent Articles
1.
Boyd A, Reid J, Salci K, Aslostovar L, Benoit Y, Shapovalova Z, et al.
Nat Cell Biol
. 2017 Oct;
19(11):1336-1347.
PMID: 29035359
Acute myeloid leukaemia (AML) is distinguished by the generation of dysfunctional leukaemic blasts, and patients characteristically suffer from fatal infections and anaemia due to insufficient normal myelo-erythropoiesis. Direct physical crowding...
2.
Lee J, Salci K, Reid J, Orlando L, Tanasijevic B, Shapovalova Z, et al.
Stem Cells
. 2017 Aug;
35(9):2095-2102.
PMID: 28758276
Induced pluripotent stem cell reprogramming has provided critical insights into disease processes by modeling the genetics and related clinical pathophysiology. Human cancer represents highly diverse genetics, as well as inter-...
3.
Benoit Y, Mitchell R, Risueno R, Orlando L, Tanasijevic B, Boyd A, et al.
Cell Chem Biol
. 2017 Jun;
24(7):833-844.e9.
PMID: 28648376
Targeting of human cancer stem cells (CSCs) requires the identification of vulnerabilities unique to CSCs versus healthy resident stem cells (SCs). Unfortunately, dysregulated pathways that support transformed CSCs, such as...
4.
Salci K, Lee J, Mitchell R, Orlando L, Fiebig-Comyn A, Shapovalova Z, et al.
Stem Cell Res
. 2015 Jul;
15(1):240-2.
PMID: 26141785
The combination of OCT4 expression and short-term exposure to reprogramming media induces a state of transcriptional plasticity in human fibroblasts, capable of responding to changes in the extracellular environment. Here...
5.
Salci K, Lee J, Mitchell R, Orlando L, Fiebig-Comyn A, Shapovalova Z, et al.
Stem Cell Res
. 2015 Jun;
15(1):221-30.
PMID: 26117529
The combination of OCT4 expression and short-term exposure to reprogramming media induces a state of transcriptional plasticity in human fibroblasts, capable of responding to changes in the extracellular environment that...
6.
Salci K, Lee J, Laronde S, Dingwall S, Kushwah R, Fiebig-Comyn A, et al.
Stem Cells
. 2015 Mar;
33(6):1839-49.
PMID: 25764124
Current treatments that use hematopoietic progenitor cell (HPC) transplantation in acute myeloid leukemia (AML) patients substantially reduce the risk of relapse, but are limited by the availability of immune compatible...
7.
McIntyre B, Alev C, Mechael R, Salci K, Lee J, Fiebig-Comyn A, et al.
Stem Cells Transl Med
. 2013 Dec;
3(1):7-17.
PMID: 24300555
Production of human embryonic stem cell (hESC)-derived lung progenitors has broad applicability for drug screening and cell therapy; however, this is complicated by limitations in demarcating phenotypic changes with functional...
8.
Boyd A, Salci K, Shapovalova Z, McIntyre B, Bhatia M
Exp Hematol
. 2013 Jun;
41(10):858-869.e4.
PMID: 23747997
Recent work has shown that leukemic stem cell self-renewal in chronic myeloid leukemia is dependent on cell-intrinsic hedgehog (Hh) signaling, and early clinical trials suggest that targeting this pathway is...
9.
Salci K, McIntyre B, Bhatia M
Curr Opin Genet Dev
. 2013 Jun;
23(5):585-90.
PMID: 23725798
Direct conversion of cellular fate provides a potential approach to generate cells of the hematopoietic lineage without the requisite reversion to a pluripotent state via somatic cell reprogramming. The utilization...