Brendan A S McIntyre
Overview
Explore the profile of Brendan A S McIntyre including associated specialties, affiliations and a list of published articles.
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20
Citations
308
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Recent Articles
1.
Son K, Mukherjee M, McIntyre B, Eguez J, Radford K, LaVigne N, et al.
J Immunol Methods
. 2017 Jun;
449:44-55.
PMID: 28647456
Clinically relevant and reliable reports derived from in vitro research are dependent on the choice of cell isolation protocols adopted between different laboratories. Peripheral blood eosinophils are conventionally isolated using...
2.
McIntyre B, Kushwah R, Mechael R, Shapovalova Z, Alev C, Bhatia M
Innate Immun
. 2014 Sep;
21(5):504-11.
PMID: 25261966
The acquisition of innate immune response is requisite to having bona fide differentiation of airway epithelium. Procedures developed to differentiate lung airway from human pluripotent stem cells (hPSCs) have demonstrated...
3.
McIntyre B, Alev C, Mechael R, Salci K, Lee J, Fiebig-Comyn A, et al.
Stem Cells Transl Med
. 2013 Dec;
3(1):7-17.
PMID: 24300555
Production of human embryonic stem cell (hESC)-derived lung progenitors has broad applicability for drug screening and cell therapy; however, this is complicated by limitations in demarcating phenotypic changes with functional...
4.
Boyd A, Salci K, Shapovalova Z, McIntyre B, Bhatia M
Exp Hematol
. 2013 Jun;
41(10):858-869.e4.
PMID: 23747997
Recent work has shown that leukemic stem cell self-renewal in chronic myeloid leukemia is dependent on cell-intrinsic hedgehog (Hh) signaling, and early clinical trials suggest that targeting this pathway is...
5.
Lee J, Werbowetski-Ogilvie T, Lee J, McIntyre B, Schnerch A, Hong S, et al.
Blood
. 2013 Jun;
122(7):1162-73.
PMID: 23733337
Notch signaling regulates several cellular processes including cell fate decisions and proliferation in both invertebrates and mice. However, comparatively less is known about the role of Notch during early human...
6.
Salci K, McIntyre B, Bhatia M
Curr Opin Genet Dev
. 2013 Jun;
23(5):585-90.
PMID: 23725798
Direct conversion of cellular fate provides a potential approach to generate cells of the hematopoietic lineage without the requisite reversion to a pluripotent state via somatic cell reprogramming. The utilization...
7.
Amyere M, Aerts V, Brouillard P, McIntyre B, Duhoux F, Wassef M, et al.
Am J Hum Genet
. 2013 Feb;
92(2):188-96.
PMID: 23375657
Inherited vascular malformations are commonly autosomal dominantly inherited with high, but incomplete, penetrance; they often present as multiple lesions. We hypothesized that Knudson's two-hit model could explain this multifocality and...
8.
McIntyre B, Ramos-Mejia V, Rampalli S, Mechael R, Lee J, Alev C, et al.
Blood
. 2013 Jan;
121(9):1543-52.
PMID: 23293081
Programs that control early lineage fate decisions and transitions from embryonic to adult human cell types during development are poorly understood. Using human pluripotent stem cells (hPSCs), in the present...
9.
Cerdan C, McIntyre B, Mechael R, Levadoux-Martin M, Yang J, Lee J, et al.
Stem Cells Dev
. 2012 May;
21(15):2866-77.
PMID: 22548442
The development of the hematopoietic system involves multiple cellular steps beginning with the formation of the mesoderm from the primitive streak, followed by emergence of precursor populations that become committed...
10.
Belik J, McIntyre B, Enomoto M, Pan J, Grasemann H, Vasquez-Vivar J
Free Radic Biol Med
. 2011 Oct;
51(12):2227-33.
PMID: 21982896
Tetrahydrobiopterin (BH4) is a regulator of endothelial nitric oxide synthase (eNOS) activity. Deficient levels result in eNOS uncoupling, with a shift from nitric oxide to superoxide generation. The hph-1 mutant...