Kyle E Murphy
Overview
Explore the profile of Kyle E Murphy including associated specialties, affiliations and a list of published articles.
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6
Citations
13
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Recent Articles
1.
Pugh B, Rao A, Angeles-Solano M, Grosser M, Brock J, Murphy K, et al.
RSC Med Chem
. 2022 Nov;
13(9):1058-1063.
PMID: 36324495
Antibiotic resistance has been a growing public health crisis since the 1980s. Therefore, it is essential not only to continue to develop novel antibiotics but also to develop new methods...
2.
Murphy K, McKay K, Schenkelberg M, Sharafi M, Vestrheim O, Ivancic M, et al.
Angew Chem Int Ed Engl
. 2022 Sep;
61(50):e202209772.
PMID: 36161747
We report a general synthetic route toward helical ladder polymers with varying spring constants, built with chirality-assisted synthesis (CAS). Under tension and compression, these shape-persistent structures do not unfold, but...
3.
Murphy K, Thacher M, Young E, Mojik V, Wolfe A
Bioorg Med Chem Lett
. 2022 Aug;
75:128955.
PMID: 36038118
Empetroxepins A and B, which are 10,11-dihydrodibenz[b,f]oxepins produced by the Black Crowberry (Empetrum nigrum), displayed weak anti-tubercular activity upon isolation, but have not been explored for antibiotic activity despite their...
4.
Murphy K, Sloan G, Lawhern G, Volk G, Shumate J, Wolfe A
Future Med Chem
. 2020 Oct;
12(22):2067-2087.
PMID: 33124460
Antibiotic drug discovery has been an essential field of research since the early 1900s, but the threat from infectious bacteria has only increased over the decades because of the emergence...
5.
Sharafi M, McKay K, Ivancic M, McCarthy D, Dudkina N, Murphy K, et al.
Chem
. 2020 Jul;
6(6):1469-1494.
PMID: 32728651
Selective catalysis at the molecular level represents a cornerstone of chemical synthesis. However, it still remains an open question how to elevate tunable catalysis to larger length scales to functionalize...
6.
Murphy K, Bocanegra J, Liu X, Chau H, Lee P, Li J, et al.
Nat Commun
. 2017 Apr;
8:14840.
PMID: 28378788
Nature has evolved selective enzymes for the efficient biosynthesis of complex products. This exceptional ability stems from adapted enzymatic pockets, which geometrically constrain reactants and stabilize specific reactive intermediates by...