Kuo-Chieh Liao
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Explore the profile of Kuo-Chieh Liao including associated specialties, affiliations and a list of published articles.
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15
Citations
355
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0
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Recent Articles
1.
Liao K, Eshaghi M, Hong Z, Saw T, Lim J, Han J, et al.
Nucleic Acids Res
. 2025 Mar;
53(4).
PMID: 40036878
Circular RNAs are an increasingly important class of RNA molecules that can be engineered as RNA vaccines and therapeutics. Here, we screened eight different group I introns for their ability...
2.
Zhang L, Seow B, Bae K, Ba K, Zhang Y, Liao K, et al.
J Control Release
. 2025 Jan;
380:108-124.
PMID: 39875076
mRNA-loaded lipid nanoparticles (mRNA-LNPs) hold great potential for disease treatment and prevention. LNPs are normally made from four lipids including ionizable lipid, helper lipid, cholesterol, and PEGylated lipid (PEG-lipid). Although...
3.
Pereira de Castro K, Abril J, Liao K, Hao H, Donohue J, Russell W, et al.
bioRxiv
. 2024 Oct;
PMID: 39416098
Recognition of the intron branchpoint during spliceosome assembly is a multistep process that defines both mRNA structure and amount. A branchpoint sequence motif UACUAAC is variably conserved in eukaryotic genomes,...
4.
Benetti A, Tan E, Chang Z, Bae K, Thwin M, Muthuramalingam R, et al.
Vaccines (Basel)
. 2024 Apr;
12(4).
PMID: 38675792
Chitosan, a natural polysaccharide derived from chitin, possesses biocompatibility, biodegradability, and mucoadhesive characteristics, making it an attractive material for the delivery of mRNA payloads to the nasal mucosa and promoting...
5.
Liao K, Xie X, Sundstrom A, Lim X, Tan K, Zhang Y, et al.
Genome Biol
. 2023 Dec;
24(1):279.
PMID: 38053173
Background: Identifying host factors is key to understanding RNA virus pathogenicity. Besides proteins, RNAs can interact with virus genomes to impact replication. Results: Here, we use proximity ligation sequencing to...
6.
Liao K, Chuo V, Fagg W, Modahl C, Widen S, Garcia-Blanco M
Nucleic Acids Res
. 2021 Aug;
49(17):10034-10045.
PMID: 34428287
Quaking (QKI) controls RNA metabolism in many biological processes including innate immunity, where its roles remain incompletely understood. To illuminate these roles, we performed genome scale transcriptome profiling in QKI...
7.
Liao K, Garcia-Blanco M
Cells
. 2021 Aug;
10(7).
PMID: 34359890
The importance of transcriptional regulation of host genes in innate immunity against viral infection has been widely recognized. More recently, post-transcriptional regulatory mechanisms have gained appreciation as an additional and...
8.
Liao K, Chuo V, Fagg W, Bradrick S, Pompon J, Garcia-Blanco M
RNA Biol
. 2019 Dec;
17(3):366-380.
PMID: 31829086
Quaking (QKI) is an RNA-binding protein (RBP) involved in multiple aspects of RNA metabolism and many biological processes. Despite a known immune function in regulating monocyte differentiation and inflammatory responses,...
9.
Liao K, Sandall C, Carlson D, Ulke-Lemee A, Platnich J, Hughes P, et al.
Arch Biochem Biophys
. 2019 Jan;
670:104-115.
PMID: 30641048
The NLRP proteins are a subfamily of the NOD-like receptor (NLR) innate immune sensors that possess an ATP-binding NACHT domain. As the most well studied member, NLRP3 can initiate the...
10.
Barrows N, Campos R, Liao K, Prasanth K, Soto-Acosta R, Yeh S, et al.
Chem Rev
. 2018 Apr;
118(8):4448-4482.
PMID: 29652486
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year....