Kuo-Chieh Lee
Overview
Explore the profile of Kuo-Chieh Lee including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
152
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Recent Articles
1.
Wang H, Pei Z, Lee K, Nikolov B, Doehner T, Puente J, et al.
Front Aging
. 2023 Jul;
4:1175601.
PMID: 37457922
Implicated in both aging and Alzheimer's disease (AD), mammalian target of rapamycin (mTOR) is overactive in AD brain and lymphocytes. Stimulated by growth factors such as insulin, mTOR monitors cell...
2.
Pei Z, Lee K, Khan A, Wang H
Crit Rev Oncog
. 2020 May;
24(3):243-250.
PMID: 32422022
Glioblastoma multiforme (GBM) is the most common and malignant glial tumor. Although pro-growth, pro-survival, and pro-metastasis insulin signaling has been proposed to be a prominent driver of GBM progression, the...
3.
Pei Z, Lee K, Khan A, Erisnor G, Wang H
Biochem Pharmacol
. 2020 Jan;
176:113814.
PMID: 31954716
Brain tumors, particularly high-grade glioblastomas, are a crucial public health issue due to poor prognosis and an extremely low survival rate. The glioblastoma multiforme (GBM) grows rapidly within its unique...
4.
Wang H, Capuano A, Khan A, Pei Z, Lee K, Bennett D, et al.
Neurobiol Aging
. 2019 Sep;
84:119-130.
PMID: 31539648
Aberrant insulin and adipokine signaling has been implicated in cognitive decline associated with both type 2 diabetes mellitus and neurodegenerative diseases. We established methods that reliably measure insulin, adiponectin and...
5.
Wang H, MacDonald M, Borgmann-Winter K, Banerjee A, Sleiman P, Tom A, et al.
Mol Psychiatry
. 2018 Sep;
25(4):750-760.
PMID: 30214040
Multiple lines of evidence point to glutamatergic signaling in the postsynaptic density (PSD) as a pathophysiologic mechanism in schizophrenia. Integral to PSD glutamatergic signaling is reciprocal interplay between GluN and...
6.
Wang H, Lee K, Pei Z, Khan A, Bakshi K, Burns L
Neurobiol Aging
. 2017 Apr;
55:99-114.
PMID: 28438486
We show that amyloid-β (Aβ) triggers a conformational change in the scaffolding protein filamin A (FLNA) to induce FLNA associations with α7-nicotinic acetylcholine receptor (α7nAChR) and toll-like receptor 4 (TLR4)....
7.
Lin S, Dolfi S, Amiri S, Li J, Budak-Alpdogan T, Lee K, et al.
Int J Oncol
. 2013 Sep;
43(6):1817-23.
PMID: 24064862
Mesenchymal stromal cells (MSCs) are multipotent fibroblast-like cells located in the bone marrow that localize to areas of tissue damage including wounds and solid tumors. Within the tumor microenvironment, MSCs...
8.
Xie X, Kerrigan J, Minko T, Garbuzenko O, Lee K, Scarborough A, et al.
Cancer Biol Ther
. 2013 Jun;
14(8):742-51.
PMID: 23792570
E2F-1, a key transcription factor necessary for cell growth, DNA repair, and differentiation, is an attractive target for development of anticancer drugs in tumors that are E2F "oncogene addicted". We...
9.
Yan H, Xu T, Zhao H, Lee K, Wang H, Zhang Y
PLoS One
. 2013 Feb;
8(2):e55276.
PMID: 23408966
Since accumulating evidence suggests the application of anesthetics may increase the risk of Alzheimer's disease (AD), we investigated the cytotoxicity of inhaled general anesthesia in neurons and its underlying mechanism....
10.
Hsieh Y, Tedeschi P, Adebisi Lawal R, Banerjee D, Scotto K, Kerrigan J, et al.
Mol Pharmacol
. 2012 Dec;
83(2):339-53.
PMID: 23197646
Dihydrofolate reductase (DHFR), because of its essential role in DNA synthesis, has been targeted for the treatment of a wide variety of human diseases, including cancer, autoimmune diseases, and infectious...