Kunal Dhume
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Explore the profile of Kunal Dhume including associated specialties, affiliations and a list of published articles.
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13
Citations
74
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Recent Articles
1.
Flores Malavet V, Dhume K, Satchmei A, Arvelo A, Beaird A, Annamalai S, et al.
J Clin Invest
. 2025 Jan;
135(1).
PMID: 39744951
The risk of severe outcomes of influenza increases during pregnancy. Whether vaccine-induced T cell memory-primed prepregnancy retains the ability to mediate protection during pregnancy, when systemic levels of several hormones...
2.
Finn C, Dhume K, Baffoe E, Kimball L, Strutt T, McKinstry K
JCI Insight
. 2024 Dec;
10(3).
PMID: 39688906
Specialized memory CD4 T cells that reside long-term within tissues are critical components of immunity at portals of pathogen entry. In the lung, such tissue-resident memory (Trm) cells are activated...
3.
Finn C, Dhume K, Prokop E, Strutt T, McKinstry K
J Immunol
. 2023 Mar;
210(9):1292-1304.
PMID: 36961447
It is generally accepted that influenza A virus (IAV) infection promotes a Th1-like CD4 T cell response and that this effector program underlies its protective impact. Canonical Th1 polarization requires...
4.
Ng T, Flores-Malavet V, Mansoor M, Arvelo A, Dhume K, Prokop E, et al.
J Immunol
. 2023 Jan;
210(5):628-639.
PMID: 36645384
Overcoming interfering impacts of pre-existing immunity to generate universally protective influenza A virus (IAV)-specific T cell immunity through vaccination is a high priority. In this study, we passively transfer varied...
5.
Dhume K, Kaye B, McKinstry K
Biomolecules
. 2022 Nov;
12(11).
PMID: 36358898
Central to the impacts of CD4 T cells, both positive in settings of infectious disease and cancer and negative in the settings of autoimmunity and allergy, is their ability to...
6.
Dhume K, Finn C, Devarajan P, Singh A, Tejero J, Prokop E, et al.
J Immunol
. 2022 Mar;
208(8):1998-2007.
PMID: 35338093
Optimal transcriptional programming needed for CD4 T cells to protect against influenza A virus (IAV) is unclear. Most IAV-primed CD4 T cells fit Th1 criteria. However, cells deficient for the...
7.
Singh A, Dhume K, Tejero J, Strutt T, McKinstry K
Sci Rep
. 2020 Jul;
10(1):12668.
PMID: 32728053
Interleukin-2 (IL-2) has both pro- and anti-inflammatory properties that have been harnessed clinically and that are used experimentally to modulate leukocyte subsets in vivo. In mice, the bioavailability and half-life...
8.
Dhume K, Finn C, Strutt T, Sell S, McKinstry K
Mucosal Immunol
. 2019 Jul;
12(5):1220-1230.
PMID: 31278374
Although clearance of many intracellular pathogens requires T-bet-dependent CD4 T cell programming, the extent to which T-bet is needed to direct protective CD4 responses against influenza is not known. Here,...
9.
Zheng T, Crews J, McGill J, Dhume K, Finn C, Strutt T, et al.
ACS Infect Dis
. 2018 Dec;
5(2):228-238.
PMID: 30521752
A well-developed, functional immune system is paramount to combat harmful attacks from pathogenic organisms and prevent infectious diseases. Newborn animals and humans have only limited immunity upon birth, but their...
10.
Tejero J, Armand N, Finn C, Dhume K, Strutt T, Chai K, et al.
Cell Immunol
. 2018 Jun;
331:121-129.
PMID: 29935764
Although cigarette smoke is known to alter immune responses, whether and how CD4 T cells are affected is not well-described. We aimed to characterize how exposure to cigarette smoke extract...