Kumi Sakurai
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Explore the profile of Kumi Sakurai including associated specialties, affiliations and a list of published articles.
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Citations
303
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Recent Articles
1.
Gilbert R, Nunez B, Sakurai K, Fielder T, Ni H
Reprod Biol Endocrinol
. 2016 Mar;
14:13.
PMID: 27009109
Background: Growing concerns about safety of ART on human gametes, embryos, clinical outcomes and long-term health of offspring require improved methods of risk assessment to provide functionally relevant assays for...
2.
Sakurai K, Talukdar I, Patil V, Dang J, Li Z, Chang K, et al.
Cell Stem Cell
. 2014 Apr;
14(4):523-34.
PMID: 24702998
The creation of induced pluripotent stem cells (iPSCs) from somatic cells by ectopic expression of transcription factors has galvanized the fields of regenerative medicine and developmental biology. Here, we report...
3.
Snead N, Wu X, Li A, Cui Q, Sakurai K, Burnett J, et al.
Nucleic Acids Res
. 2013 Apr;
41(12):6209-21.
PMID: 23620279
The canonical exogenous trigger of RNA interference (RNAi) in mammals is small interfering RNA (siRNA). One promising application of RNAi is siRNA-based therapeutics, and therefore the optimization of siRNA efficacy...
4.
Sakurai K, Amarzguioui M, Kim D, Alluin J, Heale B, Song M, et al.
Nucleic Acids Res
. 2010 Oct;
39(4):1510-25.
PMID: 20972213
RNA interference is a powerful mechanism for sequence-specific inhibition of gene expression. It is widely known that small interfering RNAs (siRNAs) targeting the same region of a target-messenger RNA can...
5.
Sakurai K, Chomchan P, Rossi J
Curr Protoc Cell Biol
. 2010 Jun;
Chapter 27:Unit 27.1.1-28.
PMID: 20521232
The discovery of RNA interference (RNAi) and related small RNA-mediated regulatory pathways has significantly altered the understanding of gene regulation in eukaryotic cells. In the RNAi pathway, small interfering RNAs...
6.
Soifer H, Sano M, Sakurai K, Chomchan P, Saetrom P, Sherman M, et al.
Nucleic Acids Res
. 2008 Oct;
36(20):6511-22.
PMID: 18927112
In humans a single species of the RNAseIII enzyme Dicer processes both microRNA precursors into miRNAs and long double-stranded RNAs into small interfering RNAs (siRNAs). An interesting but poorly understood...
7.
Ohno O, Shima Y, Ikeda Y, Sakurai K, Watanabe K, Kawai Y, et al.
Oncol Res
. 2007 Sep;
15(4):189-97.
PMID: 17822279
We previously designed and synthesized DHMEQ as an inhibitor of NF-kappaB. In the present study, we looked into the effect of DHMEQ on the cell adhesion in human umbilical vein...
8.
Castanotto D, Sakurai K, Lingeman R, Li H, Shively L, Aagaard L, et al.
Nucleic Acids Res
. 2007 Jul;
35(15):5154-64.
PMID: 17660190
Despite the great potential of RNAi, ectopic expression of shRNA or siRNAs holds the inherent risk of competition for critical RNAi components, thus altering the regulatory functions of some cellular...
9.
Asada Y, Suzuki S, Yamada M, Sakurai K, Susa H, Maeda S, et al.
Nihon Hoshasen Gijutsu Gakkai Zasshi
. 2004 Dec;
60(12):1675-81.
PMID: 15614218
Software for the estimation of patient exposure from mammography has been developed. Because it adopts average glandular dose, the estimation of patient exposure must take advantage of D(gN) (average glandular...
10.
Matsuda M, Sakurai K, Fushimi T, Yamamoto K, Rokuhara S, Hosaka N, et al.
Clin Rheumatol
. 2004 May;
23(3):246-8.
PMID: 15168155
We report a patient with sarcoidosis who showed edema in the distal portion of all extremities, particularly the legs, as seen in remitting seronegative symmetrical synovitis with pitting edema (RS3PE)....