Sarcoidosis with High Serum Levels of Vascular Endothelial Growth Factor (VEGF), Showing RS3PE-like Symptoms in Extremities

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 2004 May 29

PMID 15168155

Citations 13

Authors

Masayuki Matsuda

Kumi Sakurai

Tomohisa Fushimi

Kanji Yamamoto

Shiho Rokuhara

Naritoshi Hosaka

Shu-Ichi Ikeda

Affiliations

Soon will be listed here.

Abstract

We report a patient with sarcoidosis who showed edema in the distal portion of all extremities, particularly the legs, as seen in remitting seronegative symmetrical synovitis with pitting edema (RS3PE). Magnetic resonance imaging demonstrated diffuse abnormal intensity in subcutaneous tissues of both legs, and skin biopsy led to a diagnosis of sarcoidosis. Vascular endothelial growth factor (VEGF) showed a high serum level, which decreased soon after starting oral prednisolone, in parallel with an improvement in the limb edema. In this patient VEGF as well as infiltration by sarcoid granuloma in the skin might have played an important role in the pathogenesis of RS3PE-like symptoms in the extremities. When painful pitting edema is seen predominantly in the distal portion of all extremities, sarcoidosis as well as RS3PE should be considered as a possible diagnosis.

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