Kumar Sharma
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Explore the profile of Kumar Sharma including associated specialties, affiliations and a list of published articles.
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213
Citations
10052
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Recent Articles
1.
Holstein D, Saliba A, Lozano D, Kim J, Sharma K, Lechleiter J
bioRxiv
. 2025 Mar;
PMID: 40060617
Hyperglycemia in poorly controlled diabetes is widely recognized as detrimental to organ dysfunction. However, the acute effects of hyperglycemia on brain metabolism and function are not fully understood. The potential...
2.
Saliba A, Chen Y, Nelson J, Vetcha A, Wang W, Kang L, et al.
bioRxiv
. 2025 Mar;
PMID: 40027701
Acute kidney injury (AKI) increases mortality risk and predisposes individuals to chronic kidney disease. Metabolic pathways play a crucial role in AKI pathophysiology. Here, we investigate the potential of methylthioadenosine...
3.
Saliba A, Debnath S, Tamayo I, Lee H, Ragi N, Das F, et al.
JCI Insight
. 2025 Feb;
PMID: 39946208
Kidney dysfunction often leads to neurological impairment, yet the complex kidney-brain relationship remains elusive. We employed spatial and bulk metabolomics to investigate a mouse model of rapid kidney failure induced...
4.
Maity S, Sharma K
Kidney Int
. 2025 Jan;
107(2):225-227.
PMID: 39848743
Choline is an essential nutrient for the biosynthesis of phospholipids and neurotransmitters and controls several physiological functions in mammals. It is metabolized in the organelles within cells, including mitochondria. However,...
5.
Lee H, Sun Y, Das F, Ju W, Nair V, Kevil C, et al.
JCI Insight
. 2025 Jan;
10(1.
PMID: 39782685
The role played by anionic channels in diabetic kidney disease (DKD) is not known. Chloride channel accessory 1 (CLCA1) facilitates the activity of TMEM16A (Anoctamin-1), a Ca2+-dependent Cl- channel. We...
6.
Das F, Ghosh-Choudhury N, Kasinath B, Sharma K, Ghosh Choudhury G
PLoS One
. 2025 Jan;
20(1):e0311828.
PMID: 39761275
High glucose milieu in diabetes induces proximal tubular epithelial cells in the kidney to undergo hypertrophy and matrix protein expansion via Akt/mTORC1 signaling, leading to renal fibrosis. The familial Parkinson's...
7.
Narongkiatikhun P, Choi Y, Hampson H, Gotzamanis J, Zhang G, van Raalte D, et al.
Kidney Int Rep
. 2024 Dec;
9(12):3386-3402.
PMID: 39698345
Mitochondria are essential for cellular energy production and are implicated in numerous diseases, including diabetic kidney disease (DKD). Current evidence indicates that mitochondrial dysfunction results in alterations in several metabolic...
8.
Choi Y, Richard G, Zhang G, Hodgin J, Demeke D, Yang Y, et al.
J Clin Invest
. 2024 Oct;
134(24.
PMID: 39436695
BACKGROUNDIn type 1 diabetes (T1D), impaired insulin sensitivity may contribute to the development of diabetic kidney disease (DKD) through alterations in kidney oxidative metabolism.METHODSYoung adults with T1D (n = 30)...
9.
Pyle L, Choi Y, Narongkiatikhun P, Sharma K, Waikar S, Layton A, et al.
Clin J Am Soc Nephrol
. 2024 Oct;
19(12):1603-1612.
PMID: 39432369
No abstract available.
10.
Tamayo I, Lee H, Aslam M, Liu J, Ragi N, Karanam V, et al.
medRxiv
. 2024 Sep;
PMID: 39228698
Mechanisms underlying the cardiovascular-kidney-metabolic (CKM) syndrome are unknown, although key small molecule metabolites may be involved. Bulk and spatial metabolomics identified adenine to be upregulated and specifically enriched in coronary...