Kshiti Phulphagar
Overview
Explore the profile of Kshiti Phulphagar including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
268
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0
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Recent Articles
1.
Wang W, Dernst A, Martin B, Lorenzi L, Cadefau-Fabregat M, Phulphagar K, et al.
Cell Rep
. 2024 Sep;
43(9):114736.
PMID: 39277863
Short-chain fatty acids (SCFAs) are immunomodulatory compounds produced by the microbiome through dietary fiber fermentation. Although generally considered beneficial for gut health, patients suffering from inflammatory bowel disease (IBD) display...
2.
Abelin J, Bergstrom E, Rivera K, Taylor H, Klaeger S, Xu C, et al.
Nat Commun
. 2023 Apr;
14(1):1851.
PMID: 37012232
Serial multi-omic analysis of proteome, phosphoproteome, and acetylome provides insights into changes in protein expression, cell signaling, cross-talk and epigenetic pathways involved in disease pathology and treatment. However, ubiquitylome and...
3.
Frauenstein A, Ebner S, Hansen F, Sinha A, Phulphagar K, Swatek K, et al.
Mol Syst Biol
. 2021 Jul;
17(7):e10125.
PMID: 34318608
Cells signal through rearrangements of protein communities governed by covalent modifications and reversible interactions of distinct sets of proteins. A method that identifies those post-transcriptional modifications regulating signaling complex composition...
4.
Phulphagar K, Kuhn L, Ebner S, Frauenstein A, Swietlik J, Rieckmann J, et al.
Cell Rep
. 2021 Mar;
34(10):108826.
PMID: 33691121
A major pathway for proinflammatory protein release by macrophages is inflammasome-mediated pyroptotic cell death. As conventional secretion, unconventional secretion, and cell death are executed simultaneously, however, the cellular mechanisms regulating...
5.
Tanzer M, Frauenstein A, Stafford C, Phulphagar K, Mann M, Meissner F
Cell Rep
. 2020 Jan;
30(4):1260-1270.e5.
PMID: 31995763
The inflammatory functions of the cytokine tumor necrosis factor (TNF) rely on its ability to induce cytokine production and to induce cell death. Caspase-dependent and caspase-independent pathways-apoptosis and necroptosis, respectively-regulate...
6.
Locatelli G, Theodorou D, Kendirli A, Jordao M, Staszewski O, Phulphagar K, et al.
Nat Neurosci
. 2018 Aug;
21(9):1196-1208.
PMID: 30127427
Mononuclear phagocytes are key regulators of both tissue damage and repair in neuroinflammatory conditions such as multiple sclerosis. To examine divergent phagocyte phenotypes in the inflamed CNS, we introduce an...
7.
Pelka K, Bertheloot D, Reimer E, Phulphagar K, Schmidt S, Christ A, et al.
Immunity
. 2018 May;
48(5):911-922.e7.
PMID: 29768176
Unc-93 homolog B1 (UNC93B1) is a key regulator of nucleic acid (NA)-sensing Toll-like receptors (TLRs). Loss of NA-sensing TLR responses in UNC93B1-deficient patients facilitates Herpes simplex virus type 1 (HSV-1)...
8.
Pelka K, Phulphagar K, Zimmermann J, Stahl R, Schmid-Burgk J, Schmidt T, et al.
J Immunol
. 2014 Sep;
193(7):3257-61.
PMID: 25187660
Sensing of nucleic acids by TLRs is crucial in the host defense against viruses and bacteria. Unc-93 homolog B1 (UNC93B1) regulates the trafficking of nucleic acid-sensing TLRs from the endoplasmic...