Krzysztof Walczak
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Explore the profile of Krzysztof Walczak including associated specialties, affiliations and a list of published articles.
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Articles
28
Citations
170
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Recent Articles
1.
Zurawska K, Byczek-Wyrostek A, Kasprzycka A, Walczak K
Molecules
. 2024 Nov;
29(21).
PMID: 39519788
3,4-Dichloro-5-hydroxy-2(5)-furanone and its dibromo analog are highly reactive molecules. Both are members of the 2(5)-furanone family, which are important as pharmacophores present in drugs and natural products. Compounds possessing the...
2.
Dopierala K, Krok E, Stachowska E, Nowak-Grzebyta J, Walczak K, Andrzejewski J, et al.
Int J Mol Sci
. 2024 Nov;
25(21).
PMID: 39519151
Hydroxyapatite (HAP) is a well-established material in biomedical applications, especially for bone tissue regeneration, dental implants, and drug delivery systems. Recent research emphasizes enhancing the biocompatibility and osteoconductivity of orthopedic...
3.
Juszczak K, Szczepankiewicz W, Walczak K
Molecules
. 2024 Feb;
29(3).
PMID: 38338374
Schiff bases attract research interest due to their applications in chemical synthesis and medicinal chemistry. In recent years, benitrobenrazide and benserazide containing imine moiety have been synthesized and characterized as...
4.
Tomczyk M, Matczak K, Skonieczna M, Chulkin P, Denel-Bobrowska M, Rozycka D, et al.
Bioorg Chem
. 2023 Sep;
140:106782.
PMID: 37659149
The study investigated the structure-activity relationship of newly synthesized dye-linker-macrocycle (DLM) conjugates and the effect of each component on various biological properties, including cytotoxicity, cellular uptake, intracellular localization, interaction with...
5.
Zurawska K, Burdalska D, Skonieczna M, Byczek-Wyrostek A, Dawicka A, Kasprzycka A, et al.
Pharmaceuticals (Basel)
. 2023 Apr;
16(4).
PMID: 37111282
The pharmacological effects of the presence of a sugar moiety, 1,2,3-triazole ring and silyl groups in the structure of biologically active compounds have been extensively studied in drug design and...
6.
Walczak K, Sieminska L
Endokrynol Pol
. 2022 May;
73(2):353-360.
PMID: 35593684
Introduction: The study was designed to evaluate the effect of thyroid function on serum levels of different adipokines in obesity. We investigated relationships between the thyroid axis and serum levels...
7.
Juszczak K, Kubicka A, Kitel R, Dzido G, Labieniec-Watala M, Zawadzki S, et al.
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35269760
Hexokinase 2 (HK2), an enzyme of the sugar kinase family, plays a dual role in glucose metabolism and mediating cancer cell apoptosis, making it an attractive target for cancer therapy....
8.
Tomczyk M, Zalewski M, Jorgensen P, Wengel J, Walczak K
Pharmaceutics
. 2022 Jan;
14(1).
PMID: 35056962
Oligonucleotides with the sequences 5'-GTG AUA TGC, 5'-GCA TAU CAC and 5'-GUG ATA UGC, where U is 2'--propargyl uridine, were subjected to post-synthetic Cu(I)-catalyzed azide-alkyne cycloaddition to attach 1,4,7,10-tetraazacyclododecane (cyclen)...
9.
Zurawska K, Stokowy M, Kapica P, Olesiejuk M, Kudelko A, Papaj K, et al.
Molecules
. 2021 Dec;
26(23).
PMID: 34885815
The addition of 2-amino-1,3,4-thiadiazole derivatives with parallel iodination of differently protected glycals has been achieved using a double molar excess of molecular iodine under mild conditions. The corresponding thiadiazole derivatives...
10.
Kitel R, Byczek-Wyrostek A, Hopko K, Kasprzycka A, Walczak K
Pharmaceuticals (Basel)
. 2021 Nov;
14(11).
PMID: 34832861
The pharmacological effects of carbon to silicon bioisosteric replacements have been widely explored in drug design and medicinal chemistry. Here, we present a systematic investigation of the impact of different...