Krysta L Engel
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Explore the profile of Krysta L Engel including associated specialties, affiliations and a list of published articles.
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15
Citations
400
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Recent Articles
1.
Ohlstrom D, Walker Z, Pandey A, Davis L, Engel K, Pan Z, et al.
Cancer Res Commun
. 2024 Dec;
5(1):106-118.
PMID: 39699274
scRNA-seq was used to study a patient with high-risk multiple myeloma featuring LCE. LCE was rooted in a transcriptomic subpopulation that corresponded to a genetic subclone and established novel links...
2.
Huffines A, Engel K, French S, Zhang Y, Viktorovskaya O, Schneider D
J Biol Chem
. 2022 Nov;
298(12):102730.
PMID: 36423683
One of the first steps in ribosome biogenesis is transcription of the ribosomal DNA by RNA polymerase I (Pol I). Processing of the resultant rRNA begins cotranscriptionally, and perturbation of...
3.
Bassett J, Rimel J, Basu S, Basnet P, Luo J, Engel K, et al.
J Biol Chem
. 2022 Aug;
298(10):102433.
PMID: 36041630
TFIIH is an evolutionarily conserved complex that plays central roles in both RNA polymerase II (pol II) transcription and DNA repair. As an integral component of the pol II preinitiation...
4.
Lo H, Engel K, Goering R, Li Y, Spitale R, Taliaferro J
Curr Protoc
. 2022 May;
2(5):e424.
PMID: 35532287
The subcellular localization of specific RNA molecules promotes localized cellular activity across a variety of species and cell types. The misregulation of this RNA targeting can result in developmental defects,...
5.
Engel K, Lo H, Goering R, Li Y, Spitale R, Taliaferro J
Nucleic Acids Res
. 2021 Dec;
50(4):e24.
PMID: 34875090
Thousands of RNA species display nonuniform distribution within cells. However, quantification of the spatial patterns adopted by individual RNAs remains difficult, in part by a lack of quantitative tools for...
6.
Goering R, Engel K, Gillen A, Fong N, Bentley D, Taliaferro J
BMC Genomics
. 2021 Jun;
22(1):476.
PMID: 34174817
Background: The sequence content of the 3' UTRs of many mRNA transcripts is regulated through alternative polyadenylation (APA). The study of this process using RNAseq data, though, has been historically...
7.
Engel K, Arora A, Goering R, Lo H, Taliaferro J
Traffic
. 2020 Apr;
21(6):404-418.
PMID: 32291836
Essentially all cells contain a variety of spatially restricted regions that are important for carrying out specialized functions. Often, these regions contain specialized transcriptomes that facilitate these functions by providing...
8.
Carvill G, Engel K, Ramamurthy A, Cochran J, Roovers J, Stamberger H, et al.
Am J Hum Genet
. 2018 Dec;
103(6):1022-1029.
PMID: 30526861
Developmental and epileptic encephalopathies (DEEs) are a group of severe epilepsies characterized by refractory seizures and developmental impairment. Sequencing approaches have identified causal genetic variants in only about 50% of...
9.
Clarke A, Engel K, Giles K, Petit C, Schneider D
Proc Natl Acad Sci U S A
. 2018 Nov;
115(50):E11633-E11641.
PMID: 30482860
DNA sequence motifs that affect RNA polymerase transcription elongation are well studied in prokaryotic organisms and contribute directly to regulation of gene expression. Despite significant work on the regulation of...
10.
Blok L, Hiatt S, Bowling K, Prokop J, Engel K, Cochran J, et al.
Hum Genet
. 2018 May;
137(5):375-388.
PMID: 29740699
Many genetic causes of developmental delay and/or intellectual disability (DD/ID) are extremely rare, and robust discovery of these requires both large-scale DNA sequencing and data sharing. Here we describe a...