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Kristofer Davie

Explore the profile of Kristofer Davie including associated specialties, affiliations and a list of published articles. Areas
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Articles 20
Citations 1963
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Recent Articles
1.
Hecker N, Kempynck N, Mauduit D, Abaffyova D, Vandepoel R, Dieltiens S, et al.
Science . 2025 Feb; 387(6735):eadp3957. PMID: 39946451
Combinations of transcription factors govern the identity of cell types, which is reflected by genomic enhancer codes. We used deep learning to characterize these enhancer codes and devised three metrics...
2.
Germeys C, Vandoorne T, Davie K, Poovathingal S, Heeren K, Vermeire W, et al.
Cell Rep . 2024 Sep; 43(9):114719. PMID: 39255062
Neuroinflammation and dysregulated energy metabolism are linked to motor neuron degeneration in amyotrophic lateral sclerosis (ALS). The egl-9 family hypoxia-inducible factor (EGLN) enzymes, also known as prolyl hydroxylase domain (PHD)...
3.
Poovathingal S, Davie K, Borm L, Vandepoel R, Poulvellarie N, Verfaillie A, et al.
Cell Rep Methods . 2024 Aug; 4(8):100831. PMID: 39111312
Spatial transcriptomics workflows using barcoded capture arrays are commonly used for resolving gene expression in tissues. However, existing techniques are either limited by capture array density or are cost prohibitive...
4.
Dopp J, Ortega A, Davie K, Poovathingal S, Baz E, Liu S
Nat Neurosci . 2024 Jan; 27(2):359-372. PMID: 38263460
The sleep-wake cycle is determined by circadian and sleep homeostatic processes. However, the molecular impact of these processes and their interaction in different brain cell populations are unknown. To fill...
5.
Walgrave H, Penning A, Tosoni G, Snoeck S, Davie K, Davis E, et al.
iScience . 2023 May; 26(6):106829. PMID: 37250784
microRNA-132 (miR-132), a known neuronal regulator, is one of the most robustly downregulated microRNAs (miRNAs) in the brain of Alzheimer's disease (AD) patients. Increasing miR-132 in AD mouse brain ameliorates...
6.
Calafate S, Ozturan G, Thrupp N, Vanderlinden J, Santa-Marinha L, Morais-Ribeiro R, et al.
Nat Neurosci . 2023 May; 26(6):1021-1031. PMID: 37188873
Early Alzheimer's disease (AD) is associated with hippocampal hyperactivity and decreased sleep quality. Here we show that homeostatic mechanisms transiently counteract the increased excitatory drive to CA1 neurons in App...
7.
Iwata R, Casimir P, Erkol E, Boubakar L, Planque M, Gallego Lopez I, et al.
Science . 2023 Jan; 379(6632):eabn4705. PMID: 36705539
Neuronal development in the human cerebral cortex is considerably prolonged compared with that of other mammals. We explored whether mitochondria influence the species-specific timing of cortical neuron maturation. By comparing...
8.
Li H, Janssens J, De Waegeneer M, Kolluru S, Davie K, Gardeux V, et al.
Science . 2022 Mar; 375(6584):eabk2432. PMID: 35239393
For more than 100 years, the fruit fly has been one of the most studied model organisms. Here, we present a single-cell atlas of the adult fly, Tabula , that...
9.
Abdel Fattah A, Daza B, Rustandi G, Berrocal-Rubio M, Gorissen B, Poovathingal S, et al.
Nat Commun . 2021 May; 12(1):3192. PMID: 34045434
Tissues achieve their complex spatial organization through an interplay between gene regulatory networks, cell-cell communication, and physical interactions mediated by mechanical forces. Current strategies to generate in-vitro tissues have largely...
10.
Wouters J, Kalender-Atak Z, Minnoye L, Spanier K, De Waegeneer M, Gonzalez-Blas C, et al.
Nat Cell Biol . 2020 Aug; 22(8):986-998. PMID: 32753671
Melanoma cells can switch between a melanocytic and a mesenchymal-like state. Scattered evidence indicates that additional intermediate state(s) may exist. Here, to search for such states and decipher their underlying...