Kristjan Holt
Overview
Explore the profile of Kristjan Holt including associated specialties, affiliations and a list of published articles.
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Articles
4
Citations
56
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0
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Recent Articles
1.
Holt K, Payne E, Spires-Jones T
Brain Neurosci Adv
. 2024 Sep;
8:23982128241280001.
PMID: 39315091
Although neuritic plaques - comprised of aggregated fibrils of the misfolded protein, amyloid β (Aβ) - have formed a central focus of Alzheimer's disease (AD) research for decades, it is...
2.
Colom-Cadena M, Toombs J, Simzer E, Holt K, McGeachan R, Tulloch J, et al.
Acta Neuropathol
. 2024 Feb;
147(1):32.
PMID: 38319380
Synapse loss correlates with cognitive decline in Alzheimer's disease, and soluble oligomeric amyloid beta (Aβ) is implicated in synaptic dysfunction and loss. An important knowledge gap is the lack of...
3.
Taylor L, Simzer E, Pimblett C, Lacey-Solymar O, McGeachan R, Meftah S, et al.
Acta Neuropathol
. 2024 Jan;
147(1):7.
PMID: 38175261
Tau hyperphosphorylation and aggregation is a common feature of many dementia-causing neurodegenerative diseases. Tau can be phosphorylated at up to 85 different sites, and there is increasing interest in whether...
4.
Colom-Cadena M, Davies C, Sirisi S, Lee J, Simzer E, Tzioras M, et al.
Neuron
. 2023 May;
111(14):2170-2183.e6.
PMID: 37192625
In Alzheimer's disease, fibrillar tau pathology accumulates and spreads through the brain and synapses are lost. Evidence from mouse models indicates that tau spreads trans-synaptically from pre- to postsynapses and...