Kristina M Lemonidis
Overview
Explore the profile of Kristina M Lemonidis including associated specialties, affiliations and a list of published articles.
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5
Citations
289
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Recent Articles
1.
Yu R, Lemonidis K, Graham M, Matson J, Crooke R, Tribble D, et al.
Biochem Pharmacol
. 2008 Dec;
77(5):910-9.
PMID: 19056355
The in vivo pharmacokinetics/pharmacodynamics of 2'-O-(2-methoxyethyl) (2'-MOE) modified antisense oligonucleotides (ASOs), targeting apolipoprotein B-100 (apoB-100), were characterized in multiple species. The species-specific apoB antisense inhibitors demonstrated target apoB mRNA reduction...
2.
Graham M, Lemonidis K, Whipple C, Subramaniam A, Monia B, Crooke S, et al.
J Lipid Res
. 2007 Jan;
48(4):763-7.
PMID: 17242417
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a member of a family of proteases that is thought to promote the degradation of the low density lipoprotein receptor (LDLR) through an...
3.
Bell 3rd T, Brown J, Graham M, Lemonidis K, Crooke R, Rudel L
Arterioscler Thromb Vasc Biol
. 2006 May;
26(8):1814-20.
PMID: 16675724
Objective: The purpose of this study was to determine the effects of liver-specific inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) on the development of hypercholesterolemia and atherosclerosis in mice. Methods...
4.
Vickers T, Zhang H, Graham M, Lemonidis K, Zhao C, Dean N
J Immunol
. 2006 Mar;
176(6):3652-61.
PMID: 16517734
A number of proinflammatory cytokines, including IL-1beta, signal through the adaptor protein MyD88. This signaling leads to phosphorylation of IL-1R-associated kinase-1 (IRAK-1) and, ultimately, activation of the NF-kappaB transcription factor....
5.
Crooke R, Graham M, Lemonidis K, Whipple C, Koo S, Perera R
J Lipid Res
. 2005 Feb;
46(5):872-84.
PMID: 15716585
High levels of plasma apolipoprotein B-100 (apoB-100), the principal apolipoprotein of LDL, are associated with cardiovascular disease. We hypothesized that suppression of apoB-100 mRNA by an antisense oligonucleotide (ASO) would...