Kristina Crona
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Explore the profile of Kristina Crona including associated specialties, affiliations and a list of published articles.
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99
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Recent Articles
1.
Crona K, Krug J, Srivastava M
J Math Biol
. 2023 Mar;
86(4):62.
PMID: 36976406
Darwinian evolution is driven by random mutations, genetic recombination (gene shuffling) and selection that favors genotypes with high fitness. For systems where each genotype can be represented as a bitstring...
2.
Crona K
Elife
. 2020 Jan;
9.
PMID: 31934856
Rank orders have been studied in evolutionary biology for almost a hundred years. Constraints on the order in which mutations accumulate are known from cancer drug treatment, and order constraints...
3.
Crona K, Luo M, Greene D
J Theor Biol
. 2020 Jan;
489:110155.
PMID: 31926205
Medical practice would benefit from a thorough understanding of constraints and uncertainty in microbial evolution. Higher order epistasis refers to unexpected effects of multiple mutations even if both single mutations...
4.
Crona K
PLoS One
. 2018 Mar;
13(3):e0193123.
PMID: 29494618
We show that genetic recombination can be a powerful mechanism for escaping suboptimal peaks. Recent studies of empirical fitness landscapes reveal complex gene interactions and multiple peaks. However, classical work...
5.
Crona K, Gavryushkin A, Greene D, Beerenwinkel N
Elife
. 2017 Dec;
6.
PMID: 29260711
Darwinian fitness is a central concept in evolutionary biology. In practice, however, it is hardly possible to measure fitness for all genotypes in a natural population. Here, we present quantitative...
6.
Crona K
PLoS Genet
. 2016 Dec;
12(12):e1006322.
PMID: 28005911
Epistasis is a key concept in the theory of adaptation. Indicators of epistasis are of interest for large systems where systematic fitness measurements may not be possible. Some recent approaches...
7.
Mira P, Crona K, Greene D, Meza J, Sturmfels B, Barlow M
PLoS One
. 2015 Sep;
10(9):e0139387.
PMID: 26402904
No abstract available.
8.
Mira P, Crona K, Greene D, Meza J, Sturmfels B, Barlow M
PLoS One
. 2015 May;
10(5):e0122283.
PMID: 25946134
The development of reliable methods for restoring susceptibility after antibiotic resistance arises has proven elusive. A greater understanding of the relationship between antibiotic administration and the evolution of resistance is...
9.
Greene D, Crona K
PLoS Comput Biol
. 2014 May;
10(5):e1003520.
PMID: 24853069
It has recently been noted that the relative prevalence of the various kinds of epistasis varies along an adaptive walk. This has been explained as a result of mean regression...
10.
Crona K, Greene D, Barlow M
J Theor Biol
. 2012 Oct;
317:1-10.
PMID: 23036916
Fitness landscapes are central in the theory of adaptation. Recent work compares global and local properties of fitness landscapes. It has been shown that multi-peaked fitness landscapes have a local...