Kristin Levine
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Explore the profile of Kristin Levine including associated specialties, affiliations and a list of published articles.
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12
Citations
75
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Recent Articles
1.
Akcimen F, Paquette K, Wild Crea P, Saffie-Awad P, Achoru C, Taiwo F, et al.
medRxiv
. 2025 Jan;
PMID: 39867380
Elucidating the genetic contributions to Parkinson's disease (PD) etiology across diverse ancestries is a critical priority for the development of targeted therapies in a global context. We conducted the largest...
2.
Kuznetsov N, Daida K, Makarious M, Al-Mubarak B, Atterling Brolin K, Malik L, et al.
bioRxiv
. 2024 Nov;
PMID: 39605431
Copy Number Variations (CNVs) play pivotal roles in the etiology of complex diseases and are variable across diverse populations. Understanding the association between CNVs and disease susceptibility is of significant...
3.
Vitale D, Koretsky M, Kuznetsov N, Hong S, Martin J, James M, et al.
G3 (Bethesda)
. 2024 Nov;
15(1.
PMID: 39566101
GenoTools, a Python package, streamlines population genetics research by integrating ancestry estimation, quality control, and genome-wide association studies capabilities into efficient pipelines. By tracking samples, variants, and quality-specific measures throughout...
4.
Long R, Ballard S, Shah S, Bianchi O, Jones L, Koretsky M, et al.
medRxiv
. 2024 Nov;
PMID: 39484274
In this paper, we leveraged Large Language Models(LLMs) to accelerate data wrangling and automate labor-intensive aspects of data discovery and harmonization. This work promotes interoperability standards and enhances data discovery,...
5.
Lange L, Levine K, Fox S, Marras C, Ahmed N, Kuznetsov N, et al.
Res Sq
. 2024 Oct;
PMID: 39372927
Pathogenic variants in the gene represent the most common cause of autosomal dominant Parkinson's disease (PD) worldwide. We identified the p.L1795F variant in 14 White/European ancestry PD patients, including two...
6.
Martin J, Kuznetsov N, Levine K, Koretsky M, Hong S, Nalls M, et al.
bioRxiv
. 2024 Sep;
PMID: 39253512
Genotyping single nucleotide polymorphisms (SNPs) is fundamental to disease research, as researchers seek to establish links between genetic variation and disease. Although significant advances in genome technology have been made...
7.
Vitale D, Koretsky M, Kuznetsov N, Hong S, Martin J, James M, et al.
bioRxiv
. 2024 Apr;
PMID: 38585876
GenoTools, a Python package, streamlines population genetics research by integrating ancestry estimation, quality control (QC), and genome-wide association studies (GWAS) capabilities into efficient pipelines. By tracking samples, variants, and quality-specific...
8.
Alvarado C, Makarious M, Weller C, Vitale D, Koretsky M, Bandres-Ciga S, et al.
Am J Hum Genet
. 2024 Jan;
111(1):150-164.
PMID: 38181731
Treatments for neurodegenerative disorders remain rare, but recent FDA approvals, such as lecanemab and aducanumab for Alzheimer disease (MIM: 607822), highlight the importance of the underlying biological mechanisms in driving...
9.
Defining the causes of sporadic Parkinson's disease in the global Parkinson's genetics program (GP2)
Towns C, Richer M, Jasaityte S, Stafford E, Joubert J, Antar T, et al.
NPJ Parkinsons Dis
. 2023 Sep;
9(1):131.
PMID: 37699923
The Global Parkinson's Genetics Program (GP2) will genotype over 150,000 participants from around the world, and integrate genetic and clinical data for use in large-scale analyses to dramatically expand our...
10.
Lake J, Warly Solsberg C, Kim J, Acosta-Uribe J, Makarious M, Li Z, et al.
Mol Psychiatry
. 2023 May;
28(7):3121-3132.
PMID: 37198259
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried out in European ancestry individuals despite the known variation in genetic architecture and disease prevalence across global populations. We leveraged...