Kristin Burns-Huang
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Explore the profile of Kristin Burns-Huang including associated specialties, affiliations and a list of published articles.
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10
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148
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Recent Articles
1.
Pandey S, Singh A, Yang G, dAndrea F, Jiang X, Hartman T, et al.
Microbiol Spectr
. 2021 Sep;
9(2):e0092821.
PMID: 34550010
Phosphopantetheinyl hydrolase, PptH (Rv2795c), is a recently discovered enzyme from Mycobacterium tuberculosis that removes 4'-phosphopantetheine (Ppt) from holo-carrier proteins (CPs) and thereby opposes the action of phosphopantetheinyl transferases (PPTases). PptH...
2.
Zhang H, Hsu H, Kahne S, Hara R, Zhan W, Jiang X, et al.
J Med Chem
. 2021 May;
64(9):6262-6272.
PMID: 33949190
Treatment of tuberculosis (TB) currently takes at least 6 months. Latent (Mtb) is phenotypically tolerant to most anti-TB drugs. A key hypothesis is that drugs that kill nonreplicating (NR) Mtb...
3.
Fay A, Philip J, Saha P, Hendrickson R, Glickman M, Burns-Huang K
mBio
. 2021 Mar;
12(2).
PMID: 33785614
Chaperones aid in protein folding and maintenance of protein integrity. In doing so, they have the unique ability to directly stabilize resistance-conferring amino acid substitutions in drug targets and to...
4.
Zhan W, Hsu H, Morgan T, Ouellette T, Burns-Huang K, Hara R, et al.
J Med Chem
. 2019 Sep;
62(20):9246-9253.
PMID: 31560200
Proteasomes of pathogenic microbes have become attractive targets for anti-infectives. Coevolving with its human host, (Mtb) has developed mechanisms to resist host-imposed nitrosative and oxidative stresses. Genetic deletion or pharmacological...
5.
Burns-Huang K, Mundhra S
Tuberculosis (Edinb)
. 2019 Apr;
115:63-66.
PMID: 30948178
The Mycobacterium tuberculosis mec+-cysO-cysM gene cluster was shown to be part of a novel cysteine biosynthesis pathway in vitro, but little is known about its essentiality or role in M....
6.
Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, et al.
Science
. 2019 Feb;
363(6426).
PMID: 30705156
(Mtb) is the leading infectious cause of death in humans. Synthesis of lipids critical for Mtb's cell wall and virulence depends on phosphopantetheinyl transferase (PptT), an enzyme that transfers 4'-phosphopantetheine...
7.
Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, et al.
ACS Infect Dis
. 2018 Feb;
4(5):771-787.
PMID: 29465985
The success of Mycobacterium tuberculosis (Mtb) as a pathogen depends on the redundant and complex mechanisms it has evolved for resisting nitrosative and oxidative stresses inflicted by host immunity. Improving...
8.
Lupoli T, Vaubourgeix J, Burns-Huang K, Gold B
ACS Infect Dis
. 2018 Feb;
4(4):478-498.
PMID: 29465983
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), remains one of the world's deadliest infectious diseases and urgently requires new antibiotics to treat drug-resistant strains and to decrease the duration of...
9.
Warrier T, Kapilashrami K, Argyrou A, Ioerger T, Little D, Murphy K, et al.
Proc Natl Acad Sci U S A
. 2016 Jul;
113(31):E4523-30.
PMID: 27432954
The rising incidence of antimicrobial resistance (AMR) makes it imperative to understand the underlying mechanisms. Mycobacterium tuberculosis (Mtb) is the single leading cause of death from a bacterial pathogen and...
10.
Zhao N, Sun M, Burns-Huang K, Jiang X, Ling Y, Darby C, et al.
PLoS One
. 2015 May;
10(5):e0126211.
PMID: 25978362
Mycobacterial tuberculosis (Mtb) is able to preserve its intrabacterial pH (pHIB) near neutrality in the acidic phagosomes of immunologically activated macrophages and to cause lethal pathology in immunocompetent mice. In...