Kristian Daniel Ralph Roth
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Explore the profile of Kristian Daniel Ralph Roth including associated specialties, affiliations and a list of published articles.
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9
Citations
193
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Recent Articles
1.
Steinke S, Roth K, Englick R, Langreder N, Ballmann R, Fuhner V, et al.
Methods Mol Biol
. 2023 Sep;
2702:563-585.
PMID: 37679639
Monoclonal antibodies (mAbs) are valuable biological molecules, serving for many applications. Therefore, it is advantageous to know the interaction pattern between antibodies and their antigens. Regions on the antigen which...
2.
Ballmann R, Schneider K, Roth K, Dubel S
Methods Mol Biol
. 2023 Sep;
2702:411-417.
PMID: 37679632
The antigen-binding ability of each antibody clone selected by phage display is usually initially ranked by a screening ELISA using monovalent scFv antibody fragments. Further characterization often requires bivalent antibody...
3.
Steinke S, Roth K, Ruschig M, Langreder N, Polten S, Schneider K, et al.
Methods Mol Biol
. 2023 Sep;
2702:247-260.
PMID: 37679623
The most common and robust in vitro technology to generate monoclonal human antibodies is phage display. This technology is a widely used and powerful key technology for recombinant antibody selection....
4.
Pieper T, Roth K, Glaser V, Riet T, Buitrago-Molina L, Hagedorn M, et al.
Cells
. 2023 Jun;
12(11).
PMID: 37296574
Adoptive transfer of antigen-specific regulatory T cells (Tregs) has shown promising results in the treatment of autoimmune diseases; however, the use of polyspecific Tregs has limited effects. However, obtaining a...
5.
Roth K, Wenzel E, Ruschig M, Steinke S, Langreder N, Heine P, et al.
Front Cell Infect Microbiol
. 2021 Jul;
11:697876.
PMID: 34307196
Antibodies are essential molecules for diagnosis and treatment of diseases caused by pathogens and their toxins. Antibodies were integrated in our medical repertoire against infectious diseases more than hundred years...
6.
Bertoglio F, Fuhner V, Ruschig M, Heine P, Abassi L, Klunemann T, et al.
Cell Rep
. 2021 Jul;
36(4):109433.
PMID: 34273271
The novel betacoronavirus severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) causes a form of severe pneumonia disease called coronavirus disease 2019 (COVID-19). To develop human neutralizing anti-SARS-CoV-2 antibodies, antibody gene libraries from...
7.
Bertoglio F, Meier D, Langreder N, Steinke S, Rand U, Simonelli L, et al.
Nat Commun
. 2021 Mar;
12(1):1577.
PMID: 33707427
COVID-19 is a severe acute respiratory disease caused by SARS-CoV-2, a new recently emerged sarbecovirus. This virus uses the human ACE2 enzyme as receptor for cell entry, recognizing it with...
8.
Korn J, Schackermann D, Kirmann T, Bertoglio F, Steinke S, Heisig J, et al.
Sci Rep
. 2020 Dec;
10(1):21393.
PMID: 33288836
Antibodies are essential tools for therapy and diagnostics. Yet, production remains expensive as it is mostly done in mammalian expression systems. As most therapeutic IgG require mammalian glycosylation to interact...
9.
Fuhner V, Heine P, Zilkens K, Meier D, Roth K, Moreira G, et al.
Methods Mol Biol
. 2018 Dec;
1904:353-375.
PMID: 30539480
Antibodies are widely used in a large variety of research applications, for diagnostics and therapy of numerous diseases, primarily cancer and autoimmune diseases. Antibodies are binding specifically to target structures...