Kristen McEachern
Overview
Explore the profile of Kristen McEachern including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
873
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0
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Recent Articles
1.
Patnaik A, Weiss G, Rasco D, Blaydorn L, Mirabella A, Beeram M, et al.
Cancer Chemother Pharmacol
. 2021 Nov;
89(1):93-103.
PMID: 34750637
Purpose: New immuno-oncology therapies targeting programmed cell death receptor 1 (PD-1) have improved patient outcomes in a broad range of cancers. The objective of this analysis was to evaluate the...
2.
Pulido A, Hanggi K, Celias D, Gardner A, Li J, Batista-Bittencourt B, et al.
Immunity
. 2021 May;
54(6):1154-1167.e7.
PMID: 33979578
Blockade of the inhibitory receptor TIM-3 shows efficacy in cancer immunotherapy clinical trials. TIM-3 inhibits production of the chemokine CXCL9 by XCR1 classical dendritic cells (cDC1), thereby limiting antitumor immunity...
3.
Datar I, Sanmamed M, Wang J, Henick B, Choi J, Badri T, et al.
Clin Cancer Res
. 2019 May;
25(15):4663-4673.
PMID: 31053602
Purpose: To determine the tumor tissue/cell distribution, functional associations, and clinical significance of PD-1, LAG-3, and TIM-3 protein expression in human non-small cell lung cancer (NSCLC). Experimental Design: Using multiplexed...
4.
Cortes J, Tamura K, DeAngelo D, de Bono J, Lorente D, Minden M, et al.
Br J Cancer
. 2018 May;
118(11):1425-1433.
PMID: 29765150
Background: Proviral integration Moloney virus (PIM) kinases (PIM1, 2 and 3) are overexpressed in several tumour types and contribute to oncogenesis. AZD1208 is a potent ATP-competitive PIM kinase inhibitor investigated...
5.
Braso-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, et al.
Nat Med
. 2017 Jun;
23(6):788.
PMID: 28586336
No abstract available.
6.
Braso-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, et al.
Nat Med
. 2017 Apr;
23(4):526.
PMID: 28388604
No abstract available.
7.
Braso-Maristany F, Filosto S, Catchpole S, Marlow R, Quist J, Francesch-Domenech E, et al.
Nat Med
. 2016 Nov;
22(11):1303-1313.
PMID: 27775704
Triple-negative breast cancers (TNBCs) have poor prognosis and lack targeted therapies. Here we identified increased copy number and expression of the PIM1 proto-oncogene in genomic data sets of patients with...
8.
Cen B, Xiong Y, Song J, Mahajan S, DuPont R, McEachern K, et al.
Mol Cell Biol
. 2014 Apr;
34(13):2517-32.
PMID: 24777602
MET, the receptor for hepatocyte growth factor (HGF), plays an important role in signaling normal and tumor cell migration and invasion. Here, we describe a previously unrecognized mechanism that promotes...
9.
Keeton E, McEachern K, Dillman K, Palakurthi S, Cao Y, Grondine M, et al.
Blood
. 2013 Dec;
123(6):905-13.
PMID: 24363397
Upregulation of Pim kinases is observed in several types of leukemias and lymphomas. Pim-1, -2, and -3 promote cell proliferation and survival downstream of cytokine and growth factor signaling pathways....
10.
Hedvat M, Huszar D, Herrmann A, Gozgit J, Schroeder A, Sheehy A, et al.
Cancer Cell
. 2009 Dec;
16(6):487-97.
PMID: 19962667
Persistent activation of Stat3 is oncogenic and is prevalent in a wide variety of human cancers. Chronic cytokine stimulation is associated with Stat3 activation in some tumors, implicating cytokine receptor-associated...