Kristen McCaleb
Overview
Explore the profile of Kristen McCaleb including associated specialties, affiliations and a list of published articles.
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Articles
3
Citations
72
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0
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Recent Articles
1.
Parikh V, Caleshu C, Reuter C, Lazzeroni L, Ingles J, Garcia J, et al.
Circ Heart Fail
. 2019 Mar;
12(3):e005371.
PMID: 30871351
Background Variants in the cardiomyocyte-specific RNA splicing factor RBM20 have been linked to familial cardiomyopathy, but the causative genetic architecture and clinical consequences of this disease are incompletely defined. Methods...
2.
Gong L, Tan Y, Boice G, Abbot S, McCaleb K, Iyer P, et al.
Bioorg Med Chem Lett
. 2012 Nov;
22(24):7381-7.
PMID: 23142618
A novel series of highly selective JNK inhibitors based on the 4-quinolone scaffold was designed and synthesized. Structure based drug design was utilized to guide the compound design as well...
3.
Soth M, Abbot S, Abubakari A, Arora N, Arzeno H, Billedeau R, et al.
Bioorg Med Chem Lett
. 2011 Apr;
21(11):3452-6.
PMID: 21515047
Learnings from previous Roche p38-selective inhibitors were applied to a new fragment hit, which was optimized to a potent, exquisitely selective preclinical lead with a good pharmacokinetic profile.